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Patients with ALC \u2265350 cells\/\u03bcL at day 28 had a median overall survival (OS) of 47.4 months when compared with 17.6 months for those with an ALC &lt;350 cells\/\u03bcL (HR = 1.98, <jats:italic>P<\/jats:italic> = 0.007). Among patients who achieved a complete remission, median event\u2010free survival (EFS) for those with ALC \u2265350 cells\/\u03bcL on day 28 was 42.1 months when compared with 13.9 months in those with ALC &lt;350 cells\/\u03bcL (HR = 2.08, <jats:italic>P<\/jats:italic> = 0.006). In multivariable analysis, the ALC on day 28 (&lt;350 cells\/\u03bcL vs. \u2265350 cells\/\u03bcL, <jats:italic>P<\/jats:italic> \u2264 .0004 for OS and EFS) along with WBC at diagnosis (\u22646.0 or &gt;30.0 K\/\u03bcL vs. &gt;6.0\u201330.0 K\/\u03bcL, <jats:italic>P<\/jats:italic> \u2264 0.002 for OS and EFS) and cytogenetics (abnormal vs. normal, <jats:italic>P<\/jats:italic> = 0.002 for OS and <jats:italic>P<\/jats:italic> = 0.02 for EFS) were independent prognostic factors of both OS and EFS. Combining these three factors segregates patients in three well\u2010defined risk groups. These data suggest that ALC can be used in combination with other prognostic features to better predict outcome and that targeting the immune system to improve ALC may be a worthwhile strategy in ALL. Am. J.Hematol. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23279","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T11:35:29Z","timestamp":1339155329000},"page":"957-960","source":"Crossref","is-referenced-by-count":20,"title":["Absolute lymphocyte count at day 28 independently predicts event\u2010free and overall survival in adults with newly diagnosed acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"87","author":[{"given":"Di","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Elson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Liedtke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno 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