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The current treatment protocol for ALL involves an intense chemotherapy regimen yielding cure rates of nearly 80%. However, new therapies need to be designed not only to increase the survival rate but also to combat the risk of severe therapy associated toxicities including secondary malignancies, growth problems, organ damage, and infertility. The c\u2010Myb proto\u2010oncogene is highly expressed in immature hematopoietic cells. In this study, we demonstrate that loss of c\u2010Myb itself decreased the viability of these leukemic cells. Additionally, the inhibition of c\u2010Myb caused a decrease in cell proliferation, significantly increased the number of cells in G<jats:sub>0<\/jats:sub>\/G<jats:sub>1<\/jats:sub> phase of the cell cycle, increased the sensitivity of pre\u2010B\u2010ALL cells to cytotoxic agents in vitro, and significantly delayed disease onset in a mouse model of leukemia. Furthermore, we demonstrate that Bcl\u20102 is a target of c\u2010Myb in pre\u2010B\u2010ALL cells. Our results identify c\u2010Myb as a potential therapeutic target in pre\u2010B\u2010ALL and suggest that suppression of c\u2010Myb levels or activity, in combination with currently used therapies and\/or dose reduction, may lead to a decrease in toxicity and an increase in patient survival rates. Because c\u2010Myb is aberrantly expressed in several other malignancies, targeting c\u2010Myb will have broad clinical applications. Am. J. Hematol., 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23283","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T11:35:54Z","timestamp":1339155354000},"page":"969-976","source":"Crossref","is-referenced-by-count":24,"title":["Role of c\u2010Myb in the survival of pre B\u2010cell acute lymphoblastic leukemia and leukemogenesis"],"prefix":"10.1002","volume":"87","author":[{"given":"Purvaba J.","family":"Sarvaiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia P.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo C.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne 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