{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:11:12Z","timestamp":1791155472612,"version":"4.1.0"},"reference-count":146,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:00:00Z","timestamp":1345680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Disease overview:<\/jats:italic> The eosinophilias encompass a broad range of nonhematologic (secondary or reactive) and hematologic (primary, clonal) disorders with potential for end\u2010organ damage.<\/jats:p><jats:p><jats:italic>Diagnosis:<\/jats:italic> Hypereosinophilia has generally been defined as a peripheral blood eosinophil count greater than 1,500\/mm<jats:sup>3<\/jats:sup> and may be associated with tissue damage. After exclusion of secondary causes of eosinophilia, diagnostic evaluation of primary eosinophilias relies on a combination of morphologic review of the blood and marrow, standard cytogenetics, fluorescent in situ\u2010hybridization, flow immunocytometry, and T\u2010cell clonality assessment to detect histopathologic or clonal evidence for an acute or chronic myeloid or lymphoproliferative disorder.<\/jats:p><jats:p><jats:italic>Risk stratification:<\/jats:italic> Disease prognosis relies on identifying the subtype of eosinophilia. After evaluation of secondary causes of eosinophilia, the 2008 World Health Organization establishes a semimolecular classification scheme of disease subtypes including \u201cmyeloid and lymphoid neoplasms with eosinophilia and abnormalities of <jats:italic>PDGFRA<\/jats:italic>, <jats:italic>PDGFRB<\/jats:italic>, or <jats:italic>FGFR1,<\/jats:italic>\u201d chronic eosinophilic leukemia, not otherwise specified' (CEL, NOS), lymphocyte\u2010variant hypereosinophilia, and idiopathic hypereosinophilic syndrome (HES), which is a diagnosis of exclusion.<\/jats:p><jats:p><jats:italic>Risk\u2010adapted therapy:<\/jats:italic> The goal of therapy is to mitigate eosinophil\u2010mediated organ damage. For patients with milder forms of eosinophilia (e.g., &lt;1,500\/mm<jats:sup>3<\/jats:sup>) without symptoms or signs of organ involvement, a watch and wait approach with close\u2010follow\u2010up may be undertaken. Identification of rearranged <jats:italic>PDGFRA<\/jats:italic> or <jats:italic>PDGFRB<\/jats:italic> is critical because of the exquisite responsiveness of these diseases to imatinib. Corticosteroids are first\u2010line therapy for patients with lymphocyte\u2010variant hypereosinophilia and HES. Hydroxyurea and interferon\u2010alpha have demonstrated efficacy as initial treatment and steroid\u2010refractory cases of HES. In addition to hydroxyurea, second line cytotoxic chemotherapy agents and hematopoietic cell transplant have been used for aggressive forms of HES and CEL with outcomes reported for limited numbers of patients. Although clinical trials have been performed with anti IL\u20105 (mepolizumab) and anti\u2010CD52 (alemtuzumab) antibodies, their therapeutic role in primary eosinophilic diseases and HES has yet to be established. Am. J. Hematol. 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23293","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T12:15:52Z","timestamp":1345724152000},"page":"903-914","source":"Crossref","is-referenced-by-count":42,"title":["World Health Organization\u2010defined eosinophilic disorders: 2012 update on diagnosis, risk stratification, and management"],"prefix":"10.1002","volume":"87","author":[{"given":"Jason","family":"Gotlib*","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.035"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.287"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050054"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0787"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2005.11.011"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80352-9"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200301000-00017"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000193467.06938.77"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025217"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11420"},{"key":"e_1_2_10_12_2","first-page":"963","article-title":"Eosinophilia detected by automated blood cell counting in ambulatory North American outpatients. Incidence and clinical significance","volume":"121","author":"Brigden M","year":"1997","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382206"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06038.x"},{"key":"e_1_2_10_15_2","first-page":"68","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Bain BJ","year":"2008"},{"key":"e_1_2_10_16_2","first-page":"51","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Bain BJ","year":"2008"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197501000-00001"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.019"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-1-78"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.022"},{"key":"e_1_2_10_21_2","first-page":"1","article-title":"Clinical features of fifteen patients with the hypereosinophilic syndrome","volume":"52","author":"Spry CJ","year":"1983","journal-title":"Q J Med"},{"key":"e_1_2_10_22_2","first-page":"253","article-title":"Prognostic factors of hypereosinophilic syndrome. Study of 40 cases","volume":"140","author":"Lefebvre C","year":"1989","journal-title":"Ann Med Interne (Paris)"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V58.5.1012.1012"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1824"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.10.2759.2759"},{"key":"e_1_2_10_26_2","first-page":"1233","article-title":"Hypereosinophilic syndrome with extensive myocardial involvement and mitral valve thrombus instead of mural thrombi","volume":"33","author":"Tanino M","year":"1983","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951102000136"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00841-9"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03637.x"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132009000600010"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9011-2"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089169107700616"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01697986"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb07174.x"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1627"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0006"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404662"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286757"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.01.013"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-84"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.5.1735"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.10.5712"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.4.637"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910073411503"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00465.x"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199402243300804"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.1071"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.4.1416.bloodjournal8741416"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.3.994.415k26_994_1002"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097684"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.010421"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.005447"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.127003"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23193"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400839"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02097.x"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709059688"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-220145"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25036"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0947"},{"key":"e_1_2_10_61_2","volume-title":"Hematology","author":"Ackerman SJ","year":"2005"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04195.x"},{"key":"e_1_2_10_63_2","first-page":"9","article-title":"Case report: Rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate","volume":"3","author":"Schaller JL","year":"2001","journal-title":"MedGenMed"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08505-7"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00046-2"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0932698100"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2798"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07033.x"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-100164"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403600"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06221.x"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.2"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004580"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00108-9"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004457"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1932"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0285"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.181"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.11.027"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-024828"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404438101"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4263"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404266"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3103"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2393"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-2-167"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.8.2284.bloodjournal8582284"},{"key":"e_1_2_10_88_2","first-page":"651","article-title":"\u03b1IFN\u2013induced hematologic and cytogenetic remission in chronic eosinophilic leukemia with t(1;5)","volume":"84","author":"Luciano L","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199806)58:2<137::AID-AJH9>3.0.CO;2-T"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.00298.x"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90348-4"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050434"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02131.x"},{"key":"e_1_2_10_94_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085560"},{"key":"e_1_2_10_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23018"},{"key":"e_1_2_10_96_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143537"},{"key":"e_1_2_10_97_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.6075"},{"key":"e_1_2_10_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90368-X"},{"key":"e_1_2_10_99_2","doi-asserted-by":"publisher","DOI":"10.1159\/000206350"},{"key":"e_1_2_10_100_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199211000-00012"},{"key":"e_1_2_10_101_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2002.43.2.267"},{"key":"e_1_2_10_102_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910601)67:11<2826::AID-CNCR2820671119>3.0.CO;2-#"},{"key":"e_1_2_10_103_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-11-199412010-00022"},{"key":"e_1_2_10_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400717"},{"key":"e_1_2_10_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21186"},{"key":"e_1_2_10_106_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01729838"},{"key":"e_1_2_10_107_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.4.630"},{"key":"e_1_2_10_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.12.001"},{"key":"e_1_2_10_109_2","article-title":"Imatinib mesylate may induce long\u2010term clinical response in FIP1L1\u2010PDGFR\u03b1\u2010negative hypereosinophilic syndrome","author":"Helbig G","year":"2011","journal-title":"Med Onc"},{"key":"e_1_2_10_110_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116576"},{"key":"e_1_2_10_111_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031261"},{"key":"e_1_2_10_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.049"},{"key":"e_1_2_10_113_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3620"},{"key":"e_1_2_10_114_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070812"},{"key":"e_1_2_10_115_2","first-page":"329","article-title":"Reslizumab, a humanized anti\u2010IL\u20105 mAb for the treatment of eosinophil\u2010mediated inflammatory conditions","volume":"11","author":"Walsh GM","year":"2009","journal-title":"Curr Opin Mol Ther"},{"key":"e_1_2_10_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.11.044"},{"key":"e_1_2_10_117_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3153"},{"key":"e_1_2_10_118_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05206.x"},{"key":"e_1_2_10_119_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04801.x"},{"key":"e_1_2_10_120_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1302"},{"key":"e_1_2_10_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702102"},{"key":"e_1_2_10_122_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701783"},{"key":"e_1_2_10_123_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809059261"},{"key":"e_1_2_10_124_2","first-page":"647","article-title":"Hypereosinophilic syndrome: Successful allogeneic bone marrow transplantation","volume":"15","author":"Sigmund DA","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_10_125_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199602)51:2<164::AID-AJH12>3.0.CO;2-I"},{"key":"e_1_2_10_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700729"},{"key":"e_1_2_10_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703379"},{"key":"e_1_2_10_128_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03771.x"},{"key":"e_1_2_10_129_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705437"},{"key":"e_1_2_10_130_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-4-650_2"},{"key":"e_1_2_10_131_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-6-791_1"},{"key":"e_1_2_10_132_2","first-page":"83","article-title":"Management of hypereosinophilic syndrome with chronic plasma\u2010 and leukapheresis","volume":"337","author":"Chambers LA","year":"1990","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_10_133_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05309.x"},{"key":"e_1_2_10_134_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-1-109"},{"key":"e_1_2_10_135_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107689809100912"},{"key":"e_1_2_10_136_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951102000136"},{"key":"e_1_2_10_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90929-9"},{"key":"e_1_2_10_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)64701-7"},{"key":"e_1_2_10_139_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb123104.x"},{"key":"e_1_2_10_140_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2008.00639.x"},{"key":"e_1_2_10_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)00947-2"},{"key":"e_1_2_10_142_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1320"},{"key":"e_1_2_10_143_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11841"},{"key":"e_1_2_10_144_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271256"},{"key":"e_1_2_10_145_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.65.5.700"},{"key":"e_1_2_10_146_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034912"},{"key":"e_1_2_10_147_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.047530"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.23293","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.23293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:21:31Z","timestamp":1696972891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.23293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,23]]},"references-count":146,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1002\/ajh.23293"],"URL":"https:\/\/doi.org\/10.1002\/ajh.23293","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,23]]}}}