{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:52:54Z","timestamp":1763535174703},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T00:00:00Z","timestamp":1345593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute lymphoblastic leukemia (ALL) with distinct fusion transcripts has unique clinical features. In this study, the incidence, clinical characteristics, early treatment response, and outcomes of 1,004 Chinese pediatric ALLs were analyzed. Patients with <jats:italic>TEL\u2010AML1<\/jats:italic> and <jats:italic>E2A\u2010PBX1<\/jats:italic> fusion genes or other B cell precursor ALLs (BCP\u2010ALL) had favorable clinical features, were sensitive to prednisone, had low minimal residual disease (MRD), and an excellent prognosis, with a 5\u2010year event\u2010free survival (EFS) of 84\u201392%. T\u2010ALL was associated with a high WBC, increased age, more central nervous system involvement, a poor prednisone response, and high MRD, with a 5\u2010year EFS of 68.4 \u00b1 5.2%. Patients with <jats:italic>BCR\u2010ABL<\/jats:italic> and <jats:italic>MLL<\/jats:italic> rearrangements usually had adverse clinical presentations and treatment responses, and a dismal prognosis, with 5\u2010year EFS of 27.3 and 57.4%, respectively. We also showed that <jats:italic>BCR\u2010ABL<\/jats:italic> and <jats:italic>MLL<\/jats:italic> rearrangements, the prednisone response, and MRD were independent prognostic factors. Interestingly, the BCH\u20102003 protocol resulted in a better outcome for <jats:italic>E2A\u2010PBX1<\/jats:italic><jats:sup>+<\/jats:sup> patients than the CCLG\u20102008 protocol. Intermediate and late relapses were more common in <jats:italic>TEL\u2010AML1<\/jats:italic><jats:sup>+<\/jats:sup> patients and other BCP\u2010ALLs compared with other subgroups (<jats:italic>P<\/jats:italic> = 0.018). Therefore, this study suggests that a fusion gene\u2010specific chemotherapy regimen and\/or targeted therapy should be developed to improve further the cure rate of pediatric ALL. Am. J. Hematol. 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23307","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T11:11:05Z","timestamp":1341832265000},"page":"1022-1027","source":"Crossref","is-referenced-by-count":56,"title":["Clinical features, early treatment responses, and outcomes of pediatric acute lymphoblastic leukemia in china with or without specific fusion transcripts: A single institutional study of 1,004 patients"],"prefix":"10.1002","volume":"87","author":[{"given":"Chao","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Xi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Guang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Xia","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.250"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.257"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.262"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.253"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.251"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900386"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.256"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60457-2"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04584.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.2.574"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.011346"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004063421402"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-009-0023-4"},{"key":"e_1_2_6_16_2","first-page":"169","volume-title":"Flow cytometric analysis of hematologic specimen. 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