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The 2p gain was detected by FISH in 17 patients (6%, 16 CLL, and 1 cMBL) and further characterized by single nucleotide polymorphism\u2010array. Overall, unfavorable cytogenetic deletions, i.e., del(11)(q23) and del(17)(p13) (<jats:italic>P<\/jats:italic> = 0.002), were significantly more frequent in 2p gain cases, as well as unmutated status of <jats:italic>IGHV<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt; 1 \u00d7 10<jats:sup>\u22124<\/jats:sup>) and CD38 (<jats:italic>P<\/jats:italic> &lt; 1 \u00d7 10<jats:sup>\u22124<\/jats:sup>) and ZAP\u201070 positive expression (<jats:italic>P<\/jats:italic> = 0.003). Furthermore, 2p gain patients had significantly higher utilization of stereotyped B\u2010cell receptors compared with 2p negative patients (<jats:italic>P<\/jats:italic> = 0.009), and the incidence of stereotyped subset #1 in 2p gain patients was significantly higher than that found in the remaining CLLs (<jats:italic>P<\/jats:italic> = 0.031). Transcriptional profiling analysis identified several genes significantly upregulated in 2p gain CLLs, most of which mapped to 2p. Among these, <jats:italic>NCOA1<\/jats:italic> and <jats:italic>ROCK2<\/jats:italic> are known for their involvement in tumor progression in several human cancers, whereas among those located in different chromosomes, <jats:italic>CAV1<\/jats:italic> at 7q31.1 has been recently identified to play a critical role in CLL progression. Thus, 2p gain can be present since the early stages of the disease, particularly in those cases characterized by other poor prognosis markers. The finding of genes upregulated in the cells with 2p gain provides new insights to define the pathogenic role of this lesion. Am. J. Hematol. 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23340","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T04:37:21Z","timestamp":1348720641000},"page":"24-31","source":"Crossref","is-referenced-by-count":29,"title":["Chromosome 2p gain in monoclonal B\u2010cell lymphocytosis and in early stage chronic lymphocytic 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