{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:23:20Z","timestamp":1768076600192,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,8]],"date-time":"2012-12-08T00:00:00Z","timestamp":1354924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Oral mucositis (OM) is one of the most common and debilitating complications in patients undergoing intensive chemotherapy followed by hematopoietic stem cell transplantation (HSCT). The aim of this study was to evaluate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) oral spray for OM induced by intensive chemotherapy followed by HSCT. Patients were randomly assigned to either the rhEGF group or placebo group. The severity of OM and self\u2010reported quality of life (QOL) were assessed daily. A total of 58 patients were analyzed. Baseline characteristics were similar between the two groups. The incidence of NCI grade \u22652 OM was higher in the rhEGF group (78.6% vs. 50%, <jats:italic>P<\/jats:italic> = 0.0496). However, the duration of OM in patients with NCI grade \u22652 tended to be shorter in the rhEGF group (8.5 days vs. 14.5 days, <jats:italic>P<\/jats:italic> = 0.262). The QOL analysis in patients with World Health Organization (WHO) grade \u22653 OM showed that rhEGF significantly reduced limitations in swallowing (<jats:italic>P<\/jats:italic> = 0.039) and drinking (<jats:italic>P<\/jats:italic> = 0.042). The duration of hospitalization (<jats:italic>P<\/jats:italic> = 0.047), administration of total parenteral nutrition (<jats:italic>P<\/jats:italic> = 0.012), and the usage of opioid analgesics (<jats:italic>P<\/jats:italic> = 0.018) were significantly shorter in the rhEGF group with WHO grade \u22653 OM. Adverse events were mild and similar between the two groups. In conclusion, this analysis showed that rhEGF did not reduce the incidence of NCI grade \u22652 OM. However, the patients with WHO grade \u22653 OM in the rhEGF group showed better results compared to the placebo group for several secondary endpoints. Am. J. Hematol. 88:107\u2013112, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23359","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T01:19:21Z","timestamp":1353287961000},"page":"107-112","source":"Crossref","is-referenced-by-count":19,"title":["Recombinant human epidermal growth factor on oral mucositis induced by intensive chemotherapy with stem cell transplantation"],"prefix":"10.1002","volume":"88","author":[{"given":"Kyung Im","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"Cancer Research Institute Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung\u2010Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Mee","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"Cancer Research Institute Seoul National University Seoul Republic of Korea"},{"name":"Clinical Research Institute Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Mi","family":"Oh","sequence":"additional","affiliation":[{"name":"College of Pharmacy Seoul National University Seoul Republic of Korea"},{"name":"Research Institute of Pharmaceutical Sciences Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Soo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"Cancer Research Institute Seoul National University Seoul Republic of Korea"},{"name":"Clinical Research Institute Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonyang","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"Cancer Research Institute Seoul National University Seoul Republic of Korea"},{"name":"Clinical Research Institute Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung Kook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"Cancer Research Institute Seoul National University Seoul Republic of Korea"},{"name":"Clinical Research Institute Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1493","article-title":"Patterns of mucositis and pain in patients receiving preparative chemotherapy and bone marrow transplantation","volume":"20","author":"McGuire DB","year":"1993","journal-title":"Oncol Nurs Forum"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930901)72:5<1612::AID-CNCR2820720520>3.0.CO;2-Q"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11671"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2201"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.157"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040125"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2008.2001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83739-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.5.1319"},{"key":"e_1_2_6_11_1","first-page":"E620","article-title":"Effect of salivary epidermal growth factor on wound healing of tongue in mice","volume":"260","author":"Noguchi S","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.03.041"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24414"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8340"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705250"},{"key":"e_1_2_6_16_1","unstructured":"Cancer Therapy Evaluation Program Common Terminology Criteria for Adverse Events Version 4.0 DCTD NCI NIH DHHS. Available from:http:\/\/ctep.cancer.gov. Accessed June 1 2012."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530613"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2307\/2336502"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.1152"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.03.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90402-C"},{"key":"e_1_2_6_23_1","first-page":"2338","volume-title":"DeVita, Hellman & Rosenberg's Cancer: Principles & Practice of Oncology","author":"Soto E","year":"2011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1979.tb01005.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00177417"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686147"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1992.81"},{"key":"e_1_2_6_28_1","volume-title":"Pharmacotherapeutics for Advanced Practice: A Practical Approach","author":"Arcangelo VP","year":"2006"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.23359","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.23359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:23:04Z","timestamp":1697448184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.23359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,8]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/ajh.23359"],"URL":"https:\/\/doi.org\/10.1002\/ajh.23359","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,8]]}}}