{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:23:24Z","timestamp":1789017804198,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>\n                    Myeloproliferative neoplasms (MPNs) are malignant disorders originating from clonal expansion of a single neoplastic stem cell and characteristically show an increase in bone marrow reticulin fibers. Lysyl oxidases (LOXs) are copper\u2010dependent amine oxidases that play a critical role in the biogenesis of connective tissue by crosslinking extracellular matrix proteins, collagen and elastin. Expression of LOX gene family members is increased in disorders associated with increased fibrosis. To evaluate involvement of LOX gene family in various MPNs. In\u2010situ hybridization was used to detect Lysyl\u2010Oxidase family members in bone marrow biopsies from patients with different MPNs. We compared normal bone marrows and those from patients with polycythemia vera, essential thrombocythemia, chronic myeloid leukemia, and primary myelofibrosis (PMF). Serum levels of lysyl\u2010oxidase from patients with PMF and healthy controls were also examined. LOX gene family was not detected in normal bone marrows. All members of the LOX gene family were over expressed in PMF. In other MPNs a differential pattern of expression was observed. Differences in gene expression were statistically significant (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.010). The medianserum LOX levels in normal controls was 28.4\u2009\u00b1\u20092.5 ng\\ml and 44.6\u2009\u00b1\u20099.44 ng\\ml in PMF (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.02). The varying pattern of expression of LOX genes may reflect differences in the pathophysiology of bone marrow fibrosis in these MPNs. These observations could be used as the basis for future targeted therapy directed against bone marrow fibrosis. Am. J. Hematol. 88:355\u2013358, 2013. \u00a9 2013 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.23409","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T06:24:43Z","timestamp":1360304683000},"page":"355-358","source":"Crossref","is-referenced-by-count":65,"title":["The expression of lysyl\u2010oxidase gene family members in myeloproliferative neoplasms"],"prefix":"10.1002","volume":"88","author":[{"given":"T.","family":"Tadmor","sequence":"first","affiliation":[{"name":"The Hematology Unit Bnai\u2010Zion Medical Center Haifa"},{"name":"The Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bejar","sequence":"additional","affiliation":[{"name":"Department of Pathology Bnai\u2010Zion Medical Center Haifa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Attias","sequence":"additional","affiliation":[{"name":"The Hematology Unit Bnai\u2010Zion Medical Center Haifa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mischenko","sequence":"additional","affiliation":[{"name":"The Hematology Unit Bnai\u2010Zion Medical Center Haifa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sabo","sequence":"additional","affiliation":[{"name":"The Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa"},{"name":"Department of Pathology and Oncology Rambam Health Care Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Neufeld","sequence":"additional","affiliation":[{"name":"The Bruce Rappaport Faculty of Medicine Cancer and Vascular Biology Research Center Rappaport Family Institute for Research in the Medical Sciences Technion Israel Institute of Haifa  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Vadasz","sequence":"additional","affiliation":[{"name":"The Hematology Unit Bnai\u2010Zion Medical Center Haifa"},{"name":"The Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology 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