{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:47:50Z","timestamp":1789958870622,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T00:00:00Z","timestamp":1364428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Although recent studies have suggested that cessation of imatinib (IM) in chronic myeloid leukemia patients can be associated with sustained response, further validation is needed to explore predictive factors. In a prospective, multicenter study, chronic phase patients were eligible for cessation of IM therapy after more than 3 years if they had no detectable BCR\u2010ABL1 transcript for at least 2 years. A total of 48 patients with a median age of 47 years (19\u201374 years) were enrolled. Twenty patients received IM for post\u2010transplant relapse. After a median follow\u2010up of 15.8 months (1.4\u201328.2 months) after IM discontinuation, nine of the non\u2010transplant group lost undetectable molecular residual disease (UMRD) and major molecular response (MMR), whereas none of the 20 patients in the transplant group experienced UMRD loss. Probabilities for sustained MMR and UMRD were 64.4% and 66.3% in the non\u2010transplant group, respectively. Of nine patients re\u2010treated with IM, eight patients re\u2010achieved MMR at a median of 1.7 months (0.9\u20132.8 months). Seven of these patients re\u2010achieved UMRD at a median of 5.6 months (2.8\u201312.1 months). Previous transplantation, IM duration, and UMRD duration were significantly associated with sustained molecular responses. Our data strongly suggest that immunological control contributes to sustained suppression of residual leukemia cell expansion and that IM can be safely discontinued in patients with post\u2010transplant relapse. Am. J. Hematol. 88:449\u2013454, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23427","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T11:35:22Z","timestamp":1361878522000},"page":"449-454","source":"Crossref","is-referenced-by-count":52,"title":["Predictive factors for successful imatinib cessation in chronic myeloid leukemia patients treated with imatinib"],"prefix":"10.1002","volume":"88","author":[{"given":"Sung\u2010Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Cancer Research Institute, The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Hee","family":"Bang","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, 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