{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:37:52Z","timestamp":1778848672457,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Total body computed tomography (TB\u2010CT) scan is not mandatory in the diagnostic\/staging algorithm of chronic lymphocytic leukemia (CLL). The aim of this study was to determine the value and prognostic significance of TB\u2010CT scan in early stage CLL patients. Baseline TB\u2010CT scan was performed in 240 Binet stage A CLL patients (179 Rai low\u2010 and 61 Rai intermediate\u2010risk) included in a prospective multicenter observational study (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrial.gov\">clinicaltrial.gov<\/jats:ext-link> ID:NCT00917549). The cohort included 69 clinical monoclonal B lymphocytosis (cMBLs). Patients were restaged considering only radiological data. Following TB\u2010CT scans, 20% of cases reclassified as radiologic Binet (r\u2010Binet) stage B. r\u2010Binet B patients showed a higher incidence of unfavorable cytogenetic abnormalities (<jats:italic>P<\/jats:italic>\u2009=\u20090.027), as well as a shorter PFS (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). At multivariate analysis, r\u2010Binet stage [HR\u2009=\u20092.48; <jats:italic>P<\/jats:italic>\u2009=\u20090.004] and IGHV mutational status [HR\u2009=\u20093.01; <jats:italic>P<\/jats:italic>\u2009=\u20090.002] retained an independent predictive value for PFS. Among 179 Rai low\u2010risk cases, 100 were redefined as r\u2010Rai intermediate\u2010risk based upon TB\u2010CT scan data, showing a higher rate of cases with higher ZAP\u201070 (<jats:italic>P<\/jats:italic>\u2009=\u20090.033) and CD38 expression (<jats:italic>P<\/jats:italic>\u2009=\u20090.029) and \u03b22\u2010microglobulin levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), as well as a shorter PFS than those with r\u2010Rai low\u2010risk (<jats:italic>P<\/jats:italic>\u2009=\u20090.008). r\u2010Rai stage [HR\u2009=\u20092.78; <jats:italic>P<\/jats:italic>\u2009=\u20090.046] and IGHV mutational status [HR\u2009=\u20094.25; <jats:italic>P<\/jats:italic>\u2009=\u20090.009] retained a significant predictive value for PFS at multivariate analysis. Forty\u2010two percent of cMBL patients were reclassified as r\u2010small lymphocytic lymphomas (r\u2010SLLs) by TB\u2010CT scan. TB\u2010CT scan appears to provide relevant information in early stage CLL related to the potential and the timing of patients to progress towards the more advanced disease stages. Am. J. Hematol. 88:539\u2013544, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23448","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T08:43:19Z","timestamp":1365064999000},"page":"539-544","source":"Crossref","is-referenced-by-count":11,"title":["Total body computed tomography scan in the initial work\u2010up of Binet stage A chronic lymphocytic leukemia patients: Results of the prospective, multicenter O\u2010CLL1\u2010GISL study"],"prefix":"10.1002","volume":"88","author":[{"given":"Massimo","family":"Gentile","sequence":"first","affiliation":[{"name":"U.O.C. di Ematologia Azienda Ospedaliera di Cosenza  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Cutrona","sequence":"additional","affiliation":[{"name":"SS di Diagnostica Molecolare IRCCS S. 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