{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:09:17Z","timestamp":1791425357147,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Most previous studies on telomere length (TL) in chronic lymphocytic leukemia (CLL) are based on referral cohorts including a high proportion of aggressive cases. Here, the impact of TL was analyzed in a population\u2010based cohort of newly diagnosed CLL (<jats:italic>n<\/jats:italic>\u2009=\u2009265) and in relation to other prognostic markers. Short telomeres were particularly associated with high\u2010risk genetic markers, such as <jats:italic>NOTCH1, SF3B1,<\/jats:italic> or <jats:italic>TP53<\/jats:italic> aberrations, and predicted a short time to treatment (TTT) and overall survival (OS) (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). TL was an independent prognostic factor and subdivided patients with otherwise good\u2010prognostic features (e.g., mutated <jats:italic>IGHV<\/jats:italic> genes, favorable cytogenetics) into subgroups with different outcome. Furthermore, in follow\u2010up samples (<jats:italic>n<\/jats:italic>\u2009=\u2009119) taken 5\u20138 years after diagnosis, TL correlated well with TL at diagnosis and remained unaffected by treatment. Altogether, these novel data indicate that short TL already at diagnosis is associated with poor outcome in CLL and that TL can be measured at later stages of the disease.  Am. J. Hematol. 88:647\u2013651, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23466","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T08:10:55Z","timestamp":1366963855000},"page":"647-651","source":"Crossref","is-referenced-by-count":45,"title":["Short telomere length is associated with <i>NOTCH1\/SF3B1\/TP53<\/i> aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients"],"prefix":"10.1002","volume":"88","author":[{"given":"Larry","family":"Mansouri","sequence":"first","affiliation":[{"name":"Department of Immunology Genetics and Pathology Rudbeck Laboratory Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Grabowski","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences Ume\u00e5 University Ume\u00e5 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