{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:31:02Z","timestamp":1768001462674,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Cardiovascular magnetic resonance (CMR) and hepatic magnetic resonance imaging (MRI) have become reliable noninvasive tools to monitor iron excess in thalassemia major (TM) patients. However, long\u2010term studies are lacking. We reviewed CMR and hepatic MRI <jats:italic>T<\/jats:italic>2* imaging on 54 TM patients who had three or more annual measurements. They were managed on various chelation regimens. Patients were grouped according to their degree of cardiac siderosis: severe (<jats:italic>T<\/jats:italic>2*, &lt;10 msec), mild to moderate (<jats:italic>T<\/jats:italic>2*\u2009=\u200910\u201320 msec), and no cardiac siderosis (<jats:italic>T<\/jats:italic>2*, &gt;20 msec). We looked at the change in cardiac <jats:italic>T<\/jats:italic>2*, liver iron concentration (LIC) and left ventricular ejection fraction (LVEF) at years 3 and 5. In patients with severe cardiac siderosis, cardiac <jats:italic>T<\/jats:italic>2* (mean\u2009\u00b1\u2009SD) improved from 6.9\u2009\u00b1\u20091.6 at baseline to 13.6\u2009\u00b1\u200910.0 by year 5, mean \u0394<jats:italic>T<\/jats:italic>2*\u2009=\u20096.7 (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). Change in cardiac <jats:italic>T<\/jats:italic>2* at year 3 was not significant in the severe group. Patients with mild to moderate cardiac siderosis had mean cardiac <jats:italic>T<\/jats:italic>2* of 14.6\u2009\u00b1\u20092.9 at baseline which improved to 26.3\u2009\u00b1\u20099.5 by year 3, mean \u0394<jats:italic>T<\/jats:italic>2*\u2009=\u200911.7 (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). At baseline, median LICs (mg\/g dry weight) in patients with severe, mild\u2013moderate, and no cardiac siderosis were 3.6, 2.8, and 3.3, whereas LVEFs (mean\u2009\u00b1\u2009SD) (%) were 56.3\u2009\u00b1\u200910.1, 60\u2009\u00b1\u20095, and 66\u2009\u00b1\u20097.6, respectively. No significant correlation was noted between \u0394 cardiac <jats:italic>T<\/jats:italic>2* and \u0394 LIC, \u0394 cardiac <jats:italic>T<\/jats:italic>2*, and \u0394 LVEF at years 3 and 5. Throughout the observation period, patients with no cardiac siderosis maintained their cardiac <jats:italic>T<\/jats:italic>2* above 20 msec. The majority of patients with cardiac siderosis improve cardiac <jats:italic>T<\/jats:italic>2* over time with optimal chelation. Am. J. Hematol. 88:652\u2013656, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23469","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T18:39:21Z","timestamp":1367519961000},"page":"652-656","source":"Crossref","is-referenced-by-count":12,"title":["Longitudinal monitoring of cardiac siderosis using cardiovascular magnetic resonance <i>T<\/i>2* in patients with thalassemia major on various chelation regimens: A 6\u2010year study"],"prefix":"10.1002","volume":"88","author":[{"given":"Srikanth R.","family":"Ambati","sequence":"first","affiliation":[{"name":"Department of Pediatrics Memorial Sloan\u2010Kettering Cancer Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E.","family":"Randolph","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Weill Cornell Medical College New York New 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