{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:34:28Z","timestamp":1761708868089},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>The etiology and pathogenesis of ocular adnexal extranodal marginal zone lymphoma (OAEMZL) are still unknown and the association with <jats:italic>Chlamydophila psittaci (C. psittaci<\/jats:italic>) has been shown in only some geographic regions. Herein, we comprehensively examined the frequency of chromosomal translocations as well as CARD11, MYD88 (L265P), and A20 mutations\/deletions in 45 <jats:italic>C. psittaci<\/jats:italic> negative OAEMZLs. t(14;18)(q32;q21) IGH\u2010MALT1 and t(11;18)(q21;q21) API2\u2010MALT1 were not detected in any of the analyzed tumors while three tumors harbored <jats:italic>IGH<\/jats:italic> translocations to an unidentified partner. CARD11 mutations were not found in all analyzed tumors, while the MYD88 L265P mutation was detected in three (6.7%) tumors. A20 mutations and deletions were each detected in seven (15.6%) and six (13.3%) tumors, respectively. Therefore, the observed genetic aberrations could account for the activation of the nuclear factor (NF)\u2010kB signaling pathway in only a minority of the cases. Further studies are needed to identify the molecular mechanisms underlying the pathogenesis of OAEMZL. Am. J. Hematol. 88:730\u2013735, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23490","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T15:53:01Z","timestamp":1369842781000},"page":"730-735","source":"Crossref","is-referenced-by-count":32,"title":["Molecular and genomic aberrations in <i>Chlamydophila psittaci<\/i> negative ocular adnexal marginal zone lymphomas"],"prefix":"10.1002","volume":"88","author":[{"given":"Daxing","family":"Zhu","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Medicine Sylvester Comprehensive Cancer Center, University of Miami Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Offiong F.","family":"Ikpatt","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Miami Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander 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