{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:26:17Z","timestamp":1789881977960,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>To provide data for future drug evaluation, we analyzed the outcome of 393 patients aged 50 years or older (median, 64 years) with AML in first relapse after treatment in recent ALFA trials. Salvage options were retrospectively classified as follows: best supportive care (BSC), low\u2010dose cytarabine (LDAC), gemtuzumab ozogamicin (GO), intensive chemotherapy (ICT), or ICT combined with GO. Second complete remission (CR2) rate was 31% and median post\u2010relapse survival was 6.8 months (0, 17, 42.5, 53, and 80% and 3.2, 5.6, 8.9, 9, and 19.8 months in BSC, LDAC, GO, ICT, and ICT\u2009+\u2009GO subsets, respectively). Age, performance status, WBC, CR1 duration, and favorable AML karyotype, but not other cytogenetic or molecular features, influenced post\u2010relapse outcome. Multivariate adjustment and propensity score matching showed that intensive salvage (ICT\/ICT+GO\/GO versus LDAC\/BSC) was associated with longer post\u2010relapse survival, at least in patients with CR1 duration \u226512 months (<jats:italic>P<\/jats:italic>\u2009=\u20090.001 and 0.0005, respectively). Of interest, GO appeared to be as effective as standard ICT, and ICT\u2009+\u2009GO combination more effective than standard ICT. In conclusion, older patients with CR1 duration \u226512 months appeared to benefit from intensive salvage and results observed with GO\u2010containing salvage suggest that GO combination studies should be actively pursued in this setting. Am. J. Hematol. 88:758\u2013764, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23498","type":"journal-article","created":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T09:36:48Z","timestamp":1370684208000},"page":"758-764","source":"Crossref","is-referenced-by-count":47,"title":["Outcome of older patients with acute myeloid leukemia in first relapse"],"prefix":"10.1002","volume":"88","author":[{"given":"Cl\u00e9mentine","family":"Sarkozy","sequence":"first","affiliation":[{"name":"Hematology Department, H\u00f4pital Saint\u2010Louis, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP) University Paris 7 EA 3518 Paris France"},{"name":"Hematology Department, H\u00f4pital Mignot University Versailles \u2010 Saint Quentin Le Chesnay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Gardin","sequence":"additional","affiliation":[{"name":"Hematology Department, H\u00f4pital Avicenne, AP\u2010HP University Paris 13 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