{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:51:31Z","timestamp":1768474291873,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T00:00:00Z","timestamp":1377820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JPM: Speaker for Celgene, Alexion, and Eisai"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Cytotoxic chemotherapy dosages are traditionally calculated according to body surface area (BSA). No guidelines exist for chemotherapy dosing of acute myeloid leukemia (AML) patients at extremes of weight. We investigated the efficacy and safety of chemotherapy dosed according to BSA based on actual body weight (ABW) among under\/normal weight, overweight, and obese AML patients. AML patients (excluding acute promyelocytic leukemia) treated with anthracycline and cytarabine\u2010based remission induction chemotherapy from 2002 to 2009 at Cleveland Clinic were divided into three body mass index (BMI) groups: under\/normal weight (BMI <jats:styled-content>\u2264<\/jats:styled-content>24.9), overweight (BMI 25.0\u201329.9), and obese (BMI \u226530.0). Among 247 AML patients, 81 (33%) were under\/normal weight, 81 (33%) were overweight, and 85 (34%) were obese. Complete remission (CR) rates were similar among these groups (69.1, 79.0, and 76.5%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.321), as was median survival (10.7, 16.7, and 14.2 months, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.352) and 30\u2010day mortality (3.7, 2.5, 7.1%, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.331). There was no difference among groups in days to neutrophil or platelet recovery, hospitalization days for induction chemotherapy, and bacteremia. After adjustment for confounders (age, sex, BMI, white blood cells, cytogenetic risk, etiology, and bacteremia), overall survival was significantly shorter for normal weight compared to overweight (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) and obese (0.038) patients. Response rates and adverse events were not significantly different among AML patients of all weight classes when induction chemotherapy was dosed according to ABW. Induction chemotherapy in these patients can be safely dosed using ABW. Am. J. Hematol. 88:906\u2013909, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23530","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T07:54:47Z","timestamp":1373010887000},"page":"906-909","source":"Crossref","is-referenced-by-count":38,"title":["Outcomes in obese and overweight acute myeloid leukemia patients receiving chemotherapy dosed according to actual body weight"],"prefix":"10.1002","volume":"88","author":[{"given":"Candice M.","family":"Wenzell","sequence":"first","affiliation":[{"name":"Department of Pharmacy Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika M.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Earl","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Yen","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karissa N.","family":"Kusick","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali S.","family":"Advani","sequence":"additional","affiliation":[{"name":"Leukemia Program Hematologic Oncology and Blood Disorders Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt E.","family":"Kalaycio","sequence":"additional","affiliation":[{"name":"Leukemia Program Hematologic Oncology and Blood Disorders Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudipto","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Leukemia Program Hematologic Oncology and Blood Disorders Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon V.","family":"Tiu","sequence":"additional","affiliation":[{"name":"Leukemia Program Hematologic Oncology and Blood Disorders Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw P.","family":"Maciejewski","sequence":"additional","affiliation":[{"name":"Leukemia Program Hematologic Oncology and Blood Disorders Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkael A.","family":"Sekeres","sequence":"additional","affiliation":[{"name":"Leukemia Program Hematologic Oncology and Blood Disorders Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.7.2297"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1385\/MO:20:4:363"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692355"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.8.1321"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00570489"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.2938"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.07.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200039030-00004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.9436"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0772"},{"key":"e_1_2_7_12_1","first-page":"51S","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report","volume":"6","author":"National Institutes of Health","year":"1998","journal-title":"National Institutes of Health. Obes Res"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.036"},{"key":"e_1_2_7_14_1","author":"Ogden CL","year":"2012","journal-title":"Prevalence of obesity in the United States"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2012.000606"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2010.000200"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.717278"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1319-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.056390"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.203"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.23530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.23530","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.23530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.23530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.23530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T12:44:13Z","timestamp":1692535453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.23530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,30]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/ajh.23530"],"URL":"https:\/\/doi.org\/10.1002\/ajh.23530","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,30]]}}}