{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:28:15Z","timestamp":1773386895250,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Several criteria to define fitness for induction chemotherapy in elderly acute myeloid leukemia (AML) have been proposed; however, no studies have reported outcomes according to the application of a risk\u2010adapted approach. We treated 256 consecutive patients with elderly AML (\u226560 years) with a risk\u2010adapted approach based on age, comorbidity score (CS), and performance status (ECOG). Eighty\u2010five low\u2010risk patients (age\u2009\u2264\u200965 years and ECOG 0\u20131 with CS\u2009&lt;\u20092), 86 intermediate\u2010risk patients (age\u2009&gt;\u200965 years or ECOG\u2009=\u20092 with CS\u2009&lt;\u20092), and 85 high\u2010risk patients (ECOG\u2009&gt;\u20092 or CS\u2009\u2265\u20092) were treated with induction chemotherapies, including standard intensive regimens, abbreviated\u2010scheduled regimens, and modified low\u2010dose cytarabine with oral etoposide (mLDAC), respectively. Overall response rates (ORR; complete response and complete response with incomplete recovery) for these three groups were 71.8%, 60.5%, and 41.2%, respectively, without a significant difference in early death rate (17.6%, 25.6%, 23.5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.415). Among three abbreviated\u2010scheduled regimens, a gemtuzumab ozogamicin (GO)\u2010containing regimen (<jats:italic>n<\/jats:italic>\u2009=\u200943) showed a similar ORR rate (72.1%) to the intensive regimen. After achieving remission, 142 patients went on postremission treatments, including reduced\u2010intensity allogeneic transplantation (RIC, <jats:italic>n<\/jats:italic>\u2009=\u200941), standard consolidation (<jats:italic>n<\/jats:italic>\u2009=\u200971), and repeated mLDAC (<jats:italic>n<\/jats:italic>\u2009=\u200930) according to donor availability, age, ECOG, and CS. Multivariate analyses revealed that not only RIC, but also repeated mLDAC, resulted in significantly superior survival outcomes to standard consolidation independent of age, ECOG, and CS. Clinical benefits of mLDAC for high\u2010risk patients and abbreviated induction with GO for intermediate\u2010risk patients should be confirmed with further studies. Our results also suggest that RIC should be actively considered in elderly AML as a postremission treatment. Am. J. Hematol. 88:1074\u20131081, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23576","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T08:58:39Z","timestamp":1377507519000},"page":"1074-1081","source":"Crossref","is-referenced-by-count":20,"title":["Outcomes of elderly <i>de novo<\/i> acute myeloid leukemia treated by a risk\u2010adapted approach based on age, comorbidity, and performance status"],"prefix":"10.1002","volume":"88","author":[{"given":"Jae\u2010Ho","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung\u2010Sik","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee\u2010Je","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Hwan","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Ah","family":"Yahng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Seong","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Ki","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's hospital The Catholic University of Korea Seoul 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