{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:24:05Z","timestamp":1791181445175,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>We examined the baseline features and clinical outcomes of 140 patients presenting with JAK2V617F positivity and a bone marrow morphology conforming with WHO criteria of polycythemia vera (PV), but a hemoglobin level of &lt;18.5 g\/dL in males (range 16.0\u201318.4) and &lt;16.5 g\/dL in females (range 15.0\u201316.4). This cohort operationally referred to as masked PV (mPV) was compared with 257 patients with overt PV and displayed male predominance, a more frequent history of arterial thrombosis and thrombocytosis. Incidence of thrombosis was similar between the two groups but mPV displayed significantly higher rates of progression to myelofibrosis and acute leukemia and inferior survival. In multivariable analysis mPV diagnosis was an independent predictor of poor survival along with age &gt;65 years and leukocyte count &gt;10 \u00d7 10<jats:sup>9<\/jats:sup>\/L. Our data suggest that mPV is a heterogeneous myeloproliferative neoplasia and not necessarily an early\/ pre\u2010polycythemic form of classical PV that at onset in a small fraction of patients clinically may mimic essential thrombocythemia. On the other hand, the majority mPV may have a longer prodrome of undiagnosed PV or a disease biology akin to primary myelofibrosis\u2010post PV myelofibrosis that could explain the worsening of outcome in comparison to overt\/classical manifestations. Am. J. Hematol. 89:52\u201354, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23585","type":"journal-article","created":{"date-parts":[[2013,8,31]],"date-time":"2013-08-31T11:50:40Z","timestamp":1377949840000},"page":"52-54","source":"Crossref","is-referenced-by-count":129,"title":["Masked polycythemia Vera (mPV): Results of an international study"],"prefix":"10.1002","volume":"89","author":[{"given":"Tiziano","family":"Barbui","sequence":"first","affiliation":[{"name":"Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Thiele","sequence":"additional","affiliation":[{"name":"University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Gisslinger","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Finazzi","sequence":"additional","affiliation":[{"name":"Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Carobbio","sequence":"additional","affiliation":[{"name":"Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Rumi","sequence":"additional","affiliation":[{"name":"University of Pavia I.R.C.C.S. Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Luigia Randi","sequence":"additional","affiliation":[{"name":"University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Betozzi","sequence":"additional","affiliation":[{"name":"University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro M.","family":"Vannucchi","sequence":"additional","affiliation":[{"name":"University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Pieri","sequence":"additional","affiliation":[{"name":"University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Carrai","sequence":"additional","affiliation":[{"name":"University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Gisslinger","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonhard","family":"M\u00fcllauer","sequence":"additional","affiliation":[{"name":"Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"S. Bortolo Hospital Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[{"name":"Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayalew","family":"Tefferi","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0349"},{"key":"e_1_2_5_3_1","first-page":"40","volume-title":"WHO Classification of Tumours of Haematopoietic and Lympoid Tissues","author":"Thiele J","year":"2008"},{"key":"e_1_2_5_4_1","first-page":"3837","article-title":"Prospective evaluation of the World Health Organization criteria for the diagnosis of polycythemia vera","volume":"118","author":"Silver RT","year":"2011","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05517.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.067348"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05535.x"},{"key":"e_1_2_5_8_1","first-page":"213","article-title":"The rise and the fall of red cell mass measurement in polycythemia vera","volume":"4","author":"Tefferi A","year":"2005","journal-title":"Curr Hematol Rep"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21105"},{"key":"e_1_2_5_10_1","first-page":"433","article-title":"The bone marrow in polycythemia vera","volume":"12","author":"Ellis JT","year":"1975","journal-title":"Semin Hematol"},{"key":"e_1_2_5_11_1","first-page":"144","article-title":"Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies","volume":"23","author":"Ellis JT","year":"1986","journal-title":"Semin Hematol"},{"key":"e_1_2_5_12_1","first-page":"317","article-title":"Diagnostic impact of bone marrow histopathology in polycythemia vera (PV)","volume":"20","author":"Thiele J","year":"2005","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084673"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/6BQ5K8LHVYAKUAF4"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21543"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.74"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23554"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-393819"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4065\/74.2.159"},{"key":"e_1_2_5_20_1","first-page":"1194","article-title":"Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis","volume":"89","author":"Mossuz P","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209262"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.163"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.8436"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208500"}],"updated-by":[{"DOI":"10.1002\/ajh.25069","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000}}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.23585","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.23585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:34:01Z","timestamp":1696606441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.23585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,19]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/ajh.23585"],"URL":"https:\/\/doi.org\/10.1002\/ajh.23585","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,19]]}}}