{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:37:33Z","timestamp":1790505453673,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Chronic lymphocytic leukemia (CLL) with stereotyped B\u2010cell receptor (BCR) belonging to subset #1 (IGHV1\u20105\u20107\/IGKV1\u201039) display a poor outcome. To characterize their genetic and genomic features and BCR function, we selected 20 subset #1 CLL from a series of 579 cases. Subset #1 CLL, all showing unmutated IGHV, were associated with the presence of del(11q) (50%) in comparison with unmutated CLL, unmutated stereotyped CLL other than subset #1 and with cases using the same IGHV genes but a heterogeneous VH CDR3 (non\u2010subset #1 CLL). There were no distinctive features regarding CD38, ZAP\u201070, and\n                    <jats:italic>TP53<\/jats:italic>\n                    disruption.\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    ,\n                    <jats:italic>SF3B1<\/jats:italic>\n                    , and\n                    <jats:italic>BIRC3<\/jats:italic>\n                    were mutated in 15%, 0%, and 5% of cases, respectively, while\n                    <jats:italic>BIRC3<\/jats:italic>\n                    was deleted in 22% of cases. Microarray unsupervised analysis on 80 unmutated\/mutated\/stereotyped\/non\u2010stereotyped CLL showed a tight clustering of subset #1 cases. Their genomic signature exhibited several differentially expressed transcripts involved in BCR signal transduction, apoptosis regulation, cell proliferation, and oxidative processes, regardless of del(11q). Accordingly, BCR ligation with anti\u2010IgM revealed a significant higher proliferation of subset #1 versus unmutated non\u2010subset #1 CLL, both at baseline and after 24\u201348 hr stimulation. Subset #1 CLL represent a paradigmatic example of the direct link between BCR structure, function, and patients prognosis. Am. J. Hematol. 89:74\u201382, 2014. \u00a9 2013 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.23591","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T23:58:44Z","timestamp":1379030324000},"page":"74-82","source":"Crossref","is-referenced-by-count":27,"title":["Stereotyped subset #1 chronic lymphocytic leukemia: a direct link between B\u2010cell receptor structure, function, and patients' prognosis"],"prefix":"10.1002","volume":"89","author":[{"given":"Ilaria","family":"Del Giudice","sequence":"first","affiliation":[{"name":"Hematology, Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Chiaretti","sequence":"additional","affiliation":[{"name":"Hematology, Department of Cellular Biotechnologies and Hematology \u201cSapienza\u201d University Rome 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