{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:59:06Z","timestamp":1789203546461,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Interferon \u03b1 (IFN\u03b1) prolongs survival of CML patients achieving CCyR and potentially synergizes with TKIs. We report on the molecular status and long term outcome of 121 patients who were treated in Italy between 1986 and 2000 with IFN\u03b1 based therapy and who obtained CCyR. After a median follow up of 16.5 years, 74 (61%) patients were switched to standard imatinib: 48 (65%) lost the CCyR on IFN\u03b1, and 36 (75%) are alive and in CCyR; 26 (35%) were switched to imatinib when they were still in CCyR on IFN\u03b1, and all 26 are alive and in CCyR. Forty\u2010seven patients (39%) were never switched to imatinib: 24 (51%) continued and 23 (49%) discontinued IFN\u03b1, respectively, and 39\/47 (83%) are alive and in CCyR. At last follow\u2010up, the BCR\u2010ABL transcripts level was available in 96\/101 living patients (95%) The BCR\u2010ABL:ABL ratio was between 0.1 and 0.01% (MR<jats:sup>3.0<\/jats:sup>) in 17%, and less than 0.01% (MR<jats:sup>4.0<\/jats:sup>) in 81% of patients. No patient was completely molecular negative (MR<jats:sup>4.5<\/jats:sup> or MR<jats:sup>5.0<\/jats:sup>). The OS at 10 and 20 years is 92 and 84%, respectively. This study confirms that CCyR achieved with IFN\u03b1 and maintained with or without imatinib or any other therapy significantly correlates with long term survival in CML patients who mostly have MR<jats:sup>4.0<\/jats:sup>. Complete molecular response (MR<jats:sup>4.5<\/jats:sup> or MR<jats:sup>5.0<\/jats:sup>) seems to be unnecessary for such a long survival. This study further supports development of studies testing the clinical effect of the combinations of TKIs with IFN\u03b1. Am. J. Hematol. 89:119\u2013124, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23593","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:23:51Z","timestamp":1381544631000},"page":"119-124","source":"Crossref","is-referenced-by-count":14,"title":["Long term outcome of Ph+ CML patients achieving complete cytogenetic remission with interferon based therapy moving from interferon to imatinib era"],"prefix":"10.1002","volume":"89","author":[{"given":"Michele","family":"Malagola","sequence":"first","affiliation":[{"name":"Chair of Haematology, Unit of Blood Diseases and Stem Cell Transplantation University of Brescia 25100 Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Hematology, Department of Cellular Biotechnologies and Hematology Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Skert","sequence":"additional","affiliation":[{"name":"Chair of Haematology, Unit of Blood Diseases and Stem Cell Transplantation University of Brescia 25100 Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cancelli","sequence":"additional","affiliation":[{"name":"Chair of Haematology, Unit of Blood Diseases and Stem Cell Transplantation University of Brescia 25100 Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Soverini","sequence":"additional","affiliation":[{"name":"Institute of Hematology \u201cL. and A. 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