{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:32:06Z","timestamp":1791037926211,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T00:00:00Z","timestamp":1393459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Intravenous (IV) granulocyte colony stimulating factor (G\u2010CSF) might be safer and more convenient than subcutaneous (SC) administration to hospitalized hemato\u2010oncological patients receiving chemotherapy. To compare IV vs. SC G\u2010CSF administration, we conducted a randomized, open\u2010label trial. We included inpatients receiving chemotherapy for acute myeloid leukemia, acute lymphoblastic leukemia, lymphoma or multiple myeloma, and allogeneic or autologous hematopoietic cell transplantation (HCT). Patients were randomized to 5 mcg\/kg single daily dose of IV bolus versus SC filgrastim given for its clinical indications. Patients were crossed\u2010over to the alternate study arm on the subsequent chemotherapy course. The primary outcomes were time from initiation of filgrastim to recovery of stable neutrophil count of &gt;500 cells\/\u00b5L and a composite clinical outcome of infection or death assessed for the first course post\u2010randomization. The study was stopped on the second interim analysis. Of 120 patients randomized, 118 were evaluated in the first treatment course. The mean time to neutropenia resolution was longer with IV G\u2010CSF [7.9 days, 95% confidence interval (CI) 6.6\u20139.1] compared with SC G\u2010CSF (5.4 days, 95% CI 4.6\u20136.2), log\u2010rank<jats:italic>P<\/jats:italic>\u2009=\u20090.001. Longer neutropenia duration was observed in all patient subgroups, except for patients undergoing autologous HCT. There was no significant difference between groups in the occurrence of infection or death, but more deaths were observed with IV (4\/57, 7%) versus SC (1\/61, 1.6%) G\u2010CSF administration,<jats:italic>P<\/jats:italic>\u2009=\u20090.196. Similar results were observed when all 158 courses following cross\u2010over were analyzed. Patients reported similar pain and satisfaction scores in both groups. Bolus IV administration of G\u2010CSF results in longer neutropenia duration than SC administration, with no difference in clinical or quality\u2010of\u2010life measures. Am. J. Hematol. 89:243\u2013248, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23622","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T09:15:41Z","timestamp":1383297341000},"page":"243-248","source":"Crossref","is-referenced-by-count":19,"title":["Subcutaneous versus intravenous granulocyte colony stimulating factor for the treatment of neutropenia in hospitalized hemato\u2010oncological patients: Randomized controlled trial"],"prefix":"10.1002","volume":"89","author":[{"given":"Mical","family":"Paul","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases Rabin Medical Center, Beilinson Hospital Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Ram","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv 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Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Leibovici","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Medicine E, Rabin Medical Center Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meir","family":"Lahav","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva Israel"},{"name":"Medicine A, Rabin Medical Center Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Yeshurun","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Shpilberg","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Herscovici","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Wolach","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilad","family":"Itchaki","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Bar\u2010Natan","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Vidal","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Gafter\u2010Gvili","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva Israel"},{"name":"Medicine E, Rabin Medical Center Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Raanani","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Ramat\u2010Aviv Israel"},{"name":"Institute of Hematology Rabin Medical Center, Beilinson Hospital, Davidoff Cancer Center Petach Tikva 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