{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:14:40Z","timestamp":1789719280594,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    To identify prognostic factors affecting thrombosis\u2010free survival (TFS) and overall survival (OS), we report the experience of a Regional cooperative group in a real\u2010life cohort of 1,144 patients with essential thrombocythemia (ET) diagnosed from January 1979 to December 2010. There were 107 thrombotic events (9.4%) during follow\u2010up [60 (5.3%) arterial and 47 (4.1%) venous thromboses]. At univariate analysis, risk factors for a shorter TFS were: age &gt;60 years (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0054, 95% CI 1.18\u20132.6), previous thrombosis (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001, 95% CI 1.58\u20134.52) and the presence of at least one cardiovascular risk factor (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.036, 95% CI 1.15\u20133.13). Patients with a previous thrombosis occurred \u226524 months before ET diagnosis had a shorter TFS compared to patients with a previous thrombosis occurred &lt;24 months (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0029, 95% CI 1.5\u20136.1); furthermore, patients with previous thrombosis occurred &lt;24 months did not show a shorter TFS compared with patients without previous thrombosis (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.303, 95% CI 0.64\u20133.21). At multivariate analysis for TFS, only the occurrence of a previous thrombosis maintained its prognostic impact (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0004, 95% CI 1.48\u20133.79, RR 2.36). The 10\u2010year OS was 89.9% (95% CI 87.3\u201392.5): at multivariate analysis for OS, age &gt;60 years (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001), anemia (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001), male gender (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0019), previous thromboses (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0344), and white blood cell &gt;15 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/l (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0370) were independent risk factors. Previous thrombotic events in ET patients are crucial for TFS but their importance seems related not to the occurrence per se but mainly to the interval between the event and the diagnosis. Am. J. Hematol. 89:542\u2013546, 2014. \u00a9 2014 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.23685","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T00:34:45Z","timestamp":1391128485000},"page":"542-546","source":"Crossref","is-referenced-by-count":42,"title":["Thrombosis and survival in essential thrombocythemia: A regional study of 1,144 patients"],"prefix":"10.1002","volume":"89","author":[{"given":"Marco","family":"Montanaro","sequence":"first","affiliation":[{"name":"Department of Hematology Belcolle Hospital  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Latagliata","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza,\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cedrone","sequence":"additional","affiliation":[{"name":"Department of Hematology San Giovanni Hospital,  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Spadea","sequence":"additional","affiliation":[{"name":"Unit of Hematology Regina Elena National Cancer Institute  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Rago","sequence":"additional","affiliation":[{"name":"Department of Hematology Polo Universitario Pontino  Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonny","family":"Di Giandomenico","sequence":"additional","affiliation":[{"name":"Department of Hematology University \u201cTor Vergata,\u201d  Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Spirito","sequence":"additional","affiliation":[{"name":"Department of Hematology San Camillo Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Porrini","sequence":"additional","affiliation":[{"name":"Department of Hematology Sant'Andrea Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"De Muro","sequence":"additional","affiliation":[{"name":"Department of Hematology University \u201cCampus Biomedico,\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Crescenzi","family":"Leonetti","sequence":"additional","affiliation":[{"name":"Department of Hematology Sandro Pertini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Villiv\u00e0","sequence":"additional","affiliation":[{"name":"Department of Hematology Nuovo Regina Margherita Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"De Gregoris","sequence":"additional","affiliation":[{"name":"Department of Hematology Belcolle Hospital  Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza,\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Montefusco","sequence":"additional","affiliation":[{"name":"Department of Hematology Sant'Andrea Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza,\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cimino","sequence":"additional","affiliation":[{"name":"Department of Hematology Polo Universitario Pontino  Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Majolino","sequence":"additional","affiliation":[{"name":"Department of Hematology San Camillo Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriella","family":"Mazzucconi","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza,\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Alimena","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza,\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alesssandro","family":"Andriani","sequence":"additional","affiliation":[{"name":"Department of Hematology Nuovo Regina Margherita Hospital  Rome 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