{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:22:47Z","timestamp":1782814967354,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>After first\u2010line therapy, patients with Hodgkin lymphoma (HL) and aggressive non\u2010HL are followed up closely for early signs of relapse. The current follow\u2010up practice with frequent use of surveillance imaging is highly controversial and warrants a critical evaluation. Therefore, a retrospective multicenter study of relapsed HL and aggressive non\u2010HL (nodal T\u2010cell and diffuse large B\u2010cell lymphomas) was conducted. All included patients had been diagnosed during the period 2002\u20132011 and relapsed after achieving complete remission on first\u2010line therapy. Characteristics and outcome of imaging\u2010detected relapses were compared with other relapses. A total of 258 patients with recurrent lymphoma were included in the study. Relapse investigations were initiated outside preplanned visits in 52% of the patients. Relapse detection could be attributed to patient\u2010reported symptoms alone or in combination with abnormal blood tests or physical examination in 64% of the patients. Routine imaging prompted relapse investigations in 27% of the patients. The estimated number of routine scans per relapse was 91\u2013255 depending on the lymphoma subtype. Patients with imaging\u2010detected relapse had lower disease burden (<jats:italic>P<\/jats:italic>\u2009=\u20090.045) and reduced risk of death following relapse (hazard ratio\u2009=\u20090.62, <jats:italic>P<\/jats:italic>\u2009=\u20090.02 in multivariate analysis). Patient\u2010reported symptoms are still the most common factor for detecting lymphoma relapse and the high number of scans per relapse calls for improved criteria for use of surveillance imaging. However, imaging\u2010detected relapse was associated with lower disease burden and a possible survival advantage. The future role of routine surveillance imaging should be defined in a randomized trial. Am. J. Hematol. 89:575\u2013580, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23688","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T01:03:33Z","timestamp":1391475813000},"page":"575-580","source":"Crossref","is-referenced-by-count":51,"title":["Role of routine imaging in detecting recurrent lymphoma: A review of 258 patients with relapsed aggressive non\u2010Hodgkin and Hodgkin lymphoma"],"prefix":"10.1002","volume":"89","author":[{"given":"TC","family":"El\u2010Galaly","sequence":"first","affiliation":[{"name":"Department of Hematology Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Hematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Juul","family":"Mylam","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital Odense 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