{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:30:14Z","timestamp":1761895814525},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>To determine whether outcome after allogeneic hematopoietic cell transplantation (HCT) could be estimated by using peripheral white blood cell count (WBC) as a metric that integrates several aspects of HCT recovery, we conducted a retrospective study of 1,109 adult patients who underwent first allogeneic HCT from 2003 through 2009. WBC at 1\u20133 months after HCT was categorized as low (&lt;2), normal (2\u201310), and high (&gt;10 \u00d7 10<jats:sup>9<\/jats:sup> cells\/L). Overall survival (OS) and progression\u2010free survival (PFS) were lower for patients with low or high WBC at 1\u20133 months after HCT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). We developed a predictive three\u2010group risk model based on the pattern of WBC recovery early after HCT. Five\u2010year OS was 47, 30, and 15% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and 5\u2010year PFS was 39, 22, and 14% for patients in the three different risk groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The pattern of WBC recovery early after HCT provides prognostic information for relapse, nonrelapse mortality, progression\u2010free survival, and overall survival. A scoring system based on the trajectory of the WBC in the first 3 months after HCT can effectively stratify patients into three groups with different PFS and OS. If validated, this system could be useful in the clinical management of patients after HCT, and to stratify patients enrolled on HCT clinical trials. Am. J. Hematol. 89:591\u2013597, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23695","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T14:27:12Z","timestamp":1392733632000},"page":"591-597","source":"Crossref","is-referenced-by-count":18,"title":["White blood cell recovery after allogeneic hematopoietic cell transplantation predicts clinical outcome"],"prefix":"10.1002","volume":"89","author":[{"given":"Haesook T.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Computational Biology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Frederick","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Armand","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Andler","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey","family":"Cutler","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Koreth","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Edwin P.","family":"Alyea","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph H.","family":"Antin","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Soiffer","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Ritz","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent T.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Dana\u2010Farber Cancer Institute 450 Brookline Avenue Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403055"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.07.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705891"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.05.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.08.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.08.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.211"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705381"},{"key":"e_1_2_8_11_1","first-page":"174","article-title":"The impact of early CD4+ lymphocyte recovery on the outcome of patients who undergo allogeneic bone marrow or peripheral blood stem cell transplantation","volume":"10","author":"Fedele R","year":"2012","journal-title":"Blood Transfus"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.306"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-404673"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.02.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-418202"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.23695","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.23695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T03:09:14Z","timestamp":1696648154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.23695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,3]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/ajh.23695"],"URL":"https:\/\/doi.org\/10.1002\/ajh.23695","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,3]]}}}