{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:06:06Z","timestamp":1791752766741,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Initially classified in the myelodysplastic syndromes (MDSs), chronic myelomonocytic leukemia (CMML) is currently considered as a MDS\/myeloproliferative neoplasm. Two classes\u2014myelodysplastic and myeloproliferative\u2014have been distinguished upon the level of the white blood cell count (threshold 13 G\/L). We analyzed mutations in 19 genes reported in CMML to determine if and how these mutations impacted the respective prognosis of the two classes. We defined four major mutated pathways (DNA methylation, <jats:italic>ASXL1<\/jats:italic>, splicing, and signaling) and determined their prognostic impact. The number of mutated pathways impacted overall survival in the myelodysplastic class but not in the myeloproliferative class. The myeloproliferative class had a worse prognosis than the myelodysplastic class and was impacted by <jats:italic>RUNX1<\/jats:italic> mutations only. Our results argue for a reclassification of CMML based on the myelodysplastic\/myeloproliferative status. Am. J. Hematol. 89:604\u2013609, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23702","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T09:26:38Z","timestamp":1394011598000},"page":"604-609","source":"Crossref","is-referenced-by-count":45,"title":["Gene mutations differently impact the prognosis of the myelodysplastic and myeloproliferative classes of chronic myelomonocytic leukemia"],"prefix":"10.1002","volume":"89","author":[{"given":"Nathalie","family":"Cervera","sequence":"first","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille Aix\u2010Marseille University Marseille France"},{"name":"Laboratoire d'Oncologie Mol\u00e9culaire UMR1068 Inserm, CNRS UMR7258, Aix\u2010Marseille University Marseille France"},{"name":"Institut Paoli\u2010Calmettes Aix\u2010Marseille University Marseille 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