{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:03:12Z","timestamp":1788732192191,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Solitary plasmacytoma (SP) is a rare plasma cell dyscrasia characterized by the presence of bone or extramedullary plasma cell tumors. The treatment of choice is local radiotherapy (R\/T)\u2009\u00b1\u2009surgical excision. The role of adjuvant chemotherapy (C\/T) or novel agents (NA) is uncertain. Data related to prognostic factors are inconclusive. Herein, we describe the clinical features, survival and prognosis of 97 consecutive patients, 65 with bone SP (SBP), and 32 with extramedullary SP (SEP), diagnosed and treated in 12 Greek Myeloma Centers. Objective response rate (\u2265PR) and complete response (CR) was 91.8% and 61.9%, respectively, and did not differ between the 2 groups. Overall, 38 patients relapsed or progressed to multiple myeloma (MM). After a median follow\u2010up of 60 months, 5 and 10\u2010year overall survival (OS) probability was 92% and 89% in SEP and 86% and 69% in SBP, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.2). The 5\u2010 and 10\u2010year MM\u2010free survival (MMFS) probability was 90% and 70% for patients with SEP vs. 59% and 50% for patients with SBP, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.054). Overall, the 5\u2010 and 10\u2010year OS probability, plasmacytoma relapse\u2010free survival (PRFS), progression\u2010free survival and MMFS was 84% and 78%, 72% and 58%, 58% and 43%, and 70% and 59%, respectively. In the multivariate analysis, prolonged PRFS and young age were positive predictors of OS. Achievement of CR was the only positive predictor of PRFS. Immunoparesis was the only negative predictor of progression to MM. The addition of C\/T or NA\u2010based treatment increased toxicity without offering any survival advantage over R\/T. Am. J. Hematol. 89:803\u2013808, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23745","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T05:46:38Z","timestamp":1398231998000},"page":"803-808","source":"Crossref","is-referenced-by-count":59,"title":["Clinical features, outcome, and prognostic factors for survival and evolution to multiple myeloma of solitary plasmacytomas: A report of the Greek myeloma study group in 97 patients"],"prefix":"10.1002","volume":"89","author":[{"given":"Eirini","family":"Katodritou","sequence":"first","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology Theagenio Cancer Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens, School of Medicine Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argiris S.","family":"Symeonidis","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Division of Hematology Department of Internal Medicine University of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Pouli","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology St Savvas Oncology Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charikleia","family":"Kelaidi","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Hematology Department\u2010Bone Marrow Transplantation Unit George Papanicolaou Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Kyrtsonis","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Hematology Section and Laboratory First Department of Propaedeutic Medicine School of Medicine, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kotsopoulou","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology Metaxa Cancer Hospital Piraeus Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sosana","family":"Delimpasi","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology and Bone Marrow Transplantation Unit Evangelismos Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Christoforidou","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology Democritus University of Thrace Medical School Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Giannakoulas","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology University of Thessaly, School of Medicine Larisa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora\u2010Athina","family":"Viniou","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"First Department of Internal Medicine Hematology Unit, Laikon General Hospital, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterini","family":"Stefanoudaki","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology Amalia Fleming General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Hadjiaggelidou","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology Theagenio Cancer Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Christoulas","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology 251 General Air Force Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Verrou","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology Theagenio Cancer Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki","family":"Gastari","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology Theagenio Cancer Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Papadaki","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology Theagenio Cancer Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genovefa","family":"Polychronidou","sequence":"additional","affiliation":[{"name":"Greek Myeloma Study Group Athens Greece"},{"name":"Department of Hematology Theagenio Cancer Hospital Thessaloniki 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