{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:57:53Z","timestamp":1791075473080,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81090413"],"award-info":[{"award-number":["81090413"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270638"],"award-info":[{"award-number":["81270638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100362"],"award-info":[{"award-number":["81100362"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"1255 Discipline Promotion Program of Changhai Hospital, SMMU"},{"DOI":"10.13039\/501100014207","name":"National Public Health Grand Research Foundation","doi-asserted-by":"crossref","award":["201202017"],"award-info":[{"award-number":["201202017"]}],"id":[{"id":"10.13039\/501100014207","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>We retrospectively analyzed 449 patients with AML under the WHO classification of AML 2008 and probed implications of this classification in diagnosis and treatment of acute myeloid leukemia with myelodysplasia\u2010related changes (AML\u2010MRC) among them. The clinical presentations, biological features, treatments, and prognosis of patients diagnosed with AML\u2010MRC were analyzed and compared with those of AML not otherwise specified (AML\u2010NOS). In all patients, 115 (25.6%) were diagnosed as AML\u2010MRC including 64 males and 51 females with median onset age of 48 years (range from 17 to 78). Their complete remission (CR) rate was 60.9% and relapse rate was 57.1%. The observed median overall survival (OS) and disease\u2010free survival (DFS) were 10 and 5 months, respectively, which was significantly shorter than those of AML\u2010NOS patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The prognosis of AML\u2010MRC patients with myelodysplastic syndrome (MDS)\u2010related cytogenetics sole was similar to those with history of MDS or myelodysplastic\/myeloproliferative neoplasm (MDS\/MPN). Patients with MDS\u2010related cytogenetic abnormalities and\/or history of MDS or MDS\/MPN predisposed significantly shortened CR, OS, and DFS than AML\u2010MRC patients with only multilineage dysplasia (MLD) and AML\u2010NOS patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate analysis showed that age, cytogenetics, and history of MDS or MDS\/MPN were independent prognostic factors. Patient diagnosed as AML\u2010MRC presented distinctive clinical and biological features. Presence of MLD does not change the prognosis. Am. J. Hematol. 89:874\u2013881, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23772","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T04:08:56Z","timestamp":1401163736000},"page":"874-881","source":"Crossref","is-referenced-by-count":53,"title":["Characteristics of acute myeloid leukemia with myelodysplasia\u2010related changes: A retrospective analysis in a cohort of <scp>Chinese<\/scp> patients"],"prefix":"10.1002","volume":"89","author":[{"given":"Xiao\u2010Qian","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ying","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Xia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Qing","family":"L\u00fc","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Min","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital, Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb01325.x"},{"key":"e_1_2_6_3_1","volume-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. 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