{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:59:12Z","timestamp":1783796352152,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NCI","award":["KM1 CA 156726"],"award-info":[{"award-number":["KM1 CA 156726"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>There are heterogeneous approaches to cranial radiation therapy (CRT) for T\u2010lineage acute lymphoblastic leukemia (T\u2010ALL). We performed a systematic review of studies that specified a radiation strategy and reported survival for pediatric T\u2010ALL. Our analysis included 62 publications reporting 78 treatment groups (patient <jats:italic>n<\/jats:italic>\u2009=\u20095844). The average event\u2010free survival (EFS) was higher by 6% per 5 years (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Adjusting for year, EFS differed by radiation strategy. Compared to the reference group (CRT for all) which had a year\u2010adjusted EFS of 65% (95% confidence interval, CI: 61\u201369%) the adjusted EFS was significantly worse (rate difference (RD)\u2009=\u2009\u22129%, 95% CI: \u221215 to \u22122%) among studies that used a risk\u2010directed approach to CRT (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). The adjusted EFS for the other strategies were not significantly different compared to the reference group: CRT for central nervous system positive patients only (RD\u2009=\u2009\u22123%, 95% CI: \u221214 to 7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.49); CRT omitted for all patients (RD\u2009=\u20095%, 95% CI: \u22124 to 15%, <jats:italic>P<\/jats:italic>\u2009=\u20090.33). CRT may not be necessary with current chemotherapy for T\u2010ALL. These findings, however, are susceptible to bias and caution should be applied in drawing conclusions on the comparative effectiveness of alternative CRT strategies. Am. J. Hematol. 89:992\u2013997, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23784","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T09:45:54Z","timestamp":1402393554000},"page":"992-997","source":"Crossref","is-referenced-by-count":22,"title":["Cranial radiation for pediatric T\u2010lineage acute lymphoblastic leukemia: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"89","author":[{"given":"Michael J.","family":"Kelly","sequence":"first","affiliation":[{"name":"The Floating Hospital for Children at Tufts Medical Center Boston Massachusetts"},{"name":"Department of Pediatrics Tufts University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Trikalinos","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010based Medicine, School of Public Health Brown University Providence Rhode Island"},{"name":"Department of Health Services, Policy &amp; Practice, School of Public Health Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issa J.","family":"Dahabreh","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010based Medicine, School of Public Health Brown University Providence Rhode Island"},{"name":"Department of Health Services, Policy &amp; Practice, School of Public Health Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Gianferante","sequence":"additional","affiliation":[{"name":"The Floating Hospital for Children at Tufts Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tufts University School of Medicine Boston Massachusetts"},{"name":"Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Boston Massachusetts"},{"name":"Department of Medicine Tufts University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.257"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.262"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900386"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.253"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-378943"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.251"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70228-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027714"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.3927"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07769.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-338707"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-292615"},{"key":"e_1_2_7_14_1","unstructured":"KellyM TrikalinosT ParsonsS et al.Cranial irradiation for pediatric T\u2010lineage acute lymphoblastic leukemia and lymphoma: A systematic review and meta\u2010analysis. 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