{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T23:02:23Z","timestamp":1769382143720,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Centre for Research and Development, Poland","award":["N R13 0082 06"],"award-info":[{"award-number":["N R13 0082 06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Among cancers treated with allogeneic hematopoietic stem\u2010cell transplantation (HSCT), some are sensitive to natural killer (NK) cell reactivity, described as the \u201cmissing self\u201d recognition effect. However, this model disregarded the NK cell licensing effect, which highly increases the NK cell reactivity against tumor and is dependent on the coexpression of inhibitory killer cell immunoglobulin\u2010like receptor (iKIR) and its corresponding HLA Class I ligand. We assessed clinical data, HLA and donor iKIR genotyping in 283 patients with myelo\u2010 and lymphoproliferative malignancies who underwent HSCT from unrelated donors. We found dramatically reduced overall survival (OS), progression free survival (PFS), and time to progression (TTP) among patients with malignant diseases with the lack of HLA ligand cognate with this iKIR involved in NK cell licensing in corresponding donor (events 83.3% vs. 39.8%, <jats:italic>P<\/jats:italic> = 0.0010; 91.6% vs. 47.7%, <jats:italic>P<\/jats:italic> = 0.00010; and 30.0% vs. 17.3%, <jats:italic>P<\/jats:italic> = 0.013, for OS, PFS, and TTP, respectively). The extremely adverse PFS have withstand the correction when patient group was restricted to HLA mismatched donor\u2010recipient pairs. The incidence of aGvHD was comparable in two groups of patients. In malignant patients after HSCT the missing HLA ligand for iKIR involved in NK cell licensing in corresponding donor (\u201cmissing licensing proof\u201d) induced extremely adverse survival of the patients due to the progression of malignancy and not to the aGvHD. Avoiding the selection of HSCT donors with the \u201cmissing licensing proof\u201d in the malignant patient is strongly advisable.Am. J. Hematol. 89:E176\u2013E183, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23802","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T14:53:07Z","timestamp":1405435987000},"source":"Crossref","is-referenced-by-count":25,"title":["Donor NK cell licensing in control of malignancy in hematopoietic stem cell transplant recipients"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3474-7597","authenticated-orcid":false,"given":"Jacek","family":"Nowak","sequence":"first","affiliation":[{"name":"Department of Immunogenetics, Institute of Hematology and Transfusion Medicine  Warsaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Ko\u015bci\u0144ska","sequence":"additional","affiliation":[{"name":"Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry  Wroclaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Mika\u2010Witkowska","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics, Institute of Hematology and Transfusion Medicine  Warsaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rogatko\u2010Koro\u015b","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics, Institute of Hematology and Transfusion Medicine  Warsaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylwia","family":"Mizia","sequence":"additional","affiliation":[{"name":"Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry  Wroclaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Jasku\u0142a","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences  Wroclaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Polak","sequence":"additional","affiliation":[{"name":"Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry  Wroclaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Mordak\u2010Domaga\u0142a","sequence":"additional","affiliation":[{"name":"Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry  Wroclaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Lange","sequence":"additional","affiliation":[{"name":"Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry  Wroclaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gronkowska","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Internal Medicine Medical University of Warsaw  Warsaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142aw Wiktor","family":"J\u0119drzejczak","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Internal Medicine Medical University of Warsaw  Warsaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomira","family":"Kyrcz\u2010Krzemie\u0144","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Silesian Medical University  Katowice"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miros\u0142aw","family":"Markiewicz","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Silesian Medical University  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Transplantation Institute of Hematology and Transfusion Medicine, Warsaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazimierz","family":"Ha\u0142aburda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation Institute of Hematology and Transfusion Medicine, Warsaw"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Hellmann","sequence":"additional","affiliation":[{"name":"Department of Hematology and Transplantology Medical University of Gdansk"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mieczys\u0142aw","family":"Komarnicki","sequence":"additional","affiliation":[{"name":"Chair and Department of Hematology and Proliferative Diseases of Hematopoiesis Poznan University of Medical Sciences  Poznan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Gil","sequence":"additional","affiliation":[{"name":"Chair and Department of Hematology and 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