{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:49:46Z","timestamp":1790419786028,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>To investigate the characteristics and clinical course of cerebral vein thrombosis (CVT) in patients with myeloproliferative neoplasms (MPN) we compared 48 patients with MPN and CVT (group MPN\u2010CVT) to 87 with MPN and other venous thrombosis (group MPN\u2010VT) and 178 with MPN and no thrombosis (group MPN\u2010NoT) matched by sex, age at diagnosis of MPN (\u00b15 years) and type of MPN. The study population was identified among 5,500 patients with MPN, from January 1982 to June 2013. Thrombophilia abnormalities were significantly more prevalent in the MPN\u2010CVT and MPN\u2010VT than in MPN\u2010NoT group (<jats:italic>P<\/jats:italic> = 0.015), as well as the <jats:italic>JAK2<\/jats:italic> V617F mutation in patients with essential thrombocythemia (<jats:italic>P<\/jats:italic> = 0.059). Compared to MPN\u2010VT, MPN\u2010CVT patients had a higher rate of recurrent thrombosis (42% vs. 25%, <jats:italic>P<\/jats:italic> = 0.049) despite a shorter median follow\u2010up period (6.1 vs. 10.3 years, <jats:italic>P<\/jats:italic> = 0.019), a higher long\u2010term antithrombotic (94% vs. 84%, <jats:italic>P<\/jats:italic> = 0.099) and a similar cytoreductive treatment (79% vs. 70%, <jats:italic>P<\/jats:italic> = 0.311). The incidence of recurrent thrombosis was double in MPN\u2010CVT than in MPN\u2010VT group (8.8% and 4.2% patient\u2010years, <jats:italic>P<\/jats:italic> = 0.022), and CVT and unprovoked event were the only predictive variables in a multivariate model including also sex, blood count, thrombophilia, cytoreductive, and antithrombotic treatment (HR 1.97, 95%CI 1.05\u20133.72 and 2.09, 1.09\u20134.00, respectively). Am. J. Hematol. 89:E200\u2013E205, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23809","type":"journal-article","created":{"date-parts":[[2014,7,19]],"date-time":"2014-07-19T08:04:32Z","timestamp":1405757072000},"source":"Crossref","is-referenced-by-count":48,"title":["Cerebral vein thrombosis in patients with <scp>P<\/scp>hiladelphia\u2010negative myeloproliferative neoplasms An <scp>E<\/scp>uropean <scp>L<\/scp>eukemia <scp>N<\/scp>et study"],"prefix":"10.1002","volume":"89","author":[{"given":"Ida","family":"Martinelli","sequence":"first","affiliation":[{"name":"Angelo Bianchi Bonomi Hemophilia and Thrombosis Fondazione IRCCS Ca' Granda\u2014Ospedale Maggiore Policlinico, University of Milan  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Institute of Hematology Catholic University Rome 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