{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:25:13Z","timestamp":1791123913024,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL079937"],"award-info":[{"award-number":["R01-HL079937"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>While a doctor\u2010diagnosis of asthma is associated with an increased risk of pain and acute chest syndrome (ACS) in children with sickle cell anemia (SCA), little is known about the relationship between specific asthma characteristics and clinical factors and future morbidity in children with SCA. We evaluated the relationship between (i) asthma risk factors at the time of a clinical visit (respiratory symptoms, maternal history of asthma, allergy skin tests, spirometry results) and (ii) the known risk factor of ACS early in life, on prospective pain and ACS episodes in a cohort of 159 children with SCA followed from birth to a median of 14.7 years. An ACS episode prior to 4 years of age, (incidence rate ratio [IRR] = 2.84; <jats:italic>P<\/jats:italic> &lt; 0.001], female gender (IRR = 1.80; <jats:italic>P<\/jats:italic> = 0.009), and wheezing causing shortness of breath (IRR = 1.68; <jats:italic>P<\/jats:italic> = 0.042) were associated with future ACS rates. We subsequently added spirometry results (obstruction defined as FEV<jats:sub>1<\/jats:sub>\/FVC less than the lower limits of normal; and bronchodilator response, FEV<jats:sub>1<\/jats:sub> \u2265 12%) and prick skin test responses to the model. Only \u2265 2 positive skin tests had a significant effect (IRR 1.87; <jats:italic>P<\/jats:italic> = 0.01). Thus, early in life ACS events, wheezing causing shortness of breath, and \u2265 2 positive skin tests predict future ACS events. Am. J. Hematol. 89:E212\u2013E217, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23819","type":"journal-article","created":{"date-parts":[[2014,8,2]],"date-time":"2014-08-02T09:07:38Z","timestamp":1406970458000},"source":"Crossref","is-referenced-by-count":57,"title":["Factors predicting future ACS episodes in children with sickle cell anemia"],"prefix":"10.1002","volume":"89","author":[{"given":"Michael R.","family":"DeBaun","sequence":"first","affiliation":[{"name":"Department of Pediatrics Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Rodeghier","sequence":"additional","affiliation":[{"name":"Independent Statistician Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Boston Medical Center\/Boston University School of Medicine Boston 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