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The purpose of this study was to study blood cytokine levels in newly diagnosed and relapsed MCL patients with respect to patterns of abnormalities and relationship to the MCL International Prognostic Index (MIPI) score. We analyzed blood levels of 30 cytokines using a multiplex ELISA in 88 patients with newly diagnosed MCL (pre\u2010treatment levels) and 20 with relapsed MCL and compared them with controls without known lymphoma. Elevated cytokine levels were compared with clinical outcome and the MIPI score. In the 88 newly diagnosed MCL patients, we found significantly elevated levels compared with controls of IL\u201012, IP\u201010, sIL\u20102R\u03b1, MIG, IL\u20101RA, IL\u20108, MIP\u20101\u03b1, and MIP\u20101\u03b2 (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Of these elevated cytokines, sIL\u20102R\u03b1, IL\u20108, MIG, MIP\u20101\u03b1, and MIP\u20101\u03b2 were predictive of inferior event\u2010free survival, and sIL\u20102R\u03b1 (HR\u2009=\u20091.94; <jats:italic>P<\/jats:italic>\u2009=\u20090.038), IL\u20108 (HR\u2009=\u20092.17; <jats:italic>P<\/jats:italic>\u2009=\u20090.015), and MIP\u20101\u03b2 (HR\u2009=\u20092.10; <jats:italic>P<\/jats:italic>\u2009=\u20090.016) were independent of MIPI score; only sIL\u20102R\u03b1 (HR\u2009=\u20092.35; <jats:italic>P<\/jats:italic>\u2009=\u20090.041) was associated with overall survival after adjustment for MIPI. In the relapsed MCL patient group, the only significantly elevated plasma cytokines that predicted EFS were sIL\u20102R\u03b1 (HR\u2009=\u20092.90; <jats:italic>P<\/jats:italic>\u2009=\u20090.04) and IL\u20108 (HR\u2009=\u20093.75; <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Elevated blood levels of sIL\u20102R\u03b1 and the pro\u2010inflammatory cytokines IL\u20108 and MIP\u20101\u03b2 are poor prognostic factors in MCL patients and independent of MIPI score. These factors, if validated, will provide important additions to the MIPI and guide the development of new therapies for patients with elevated levels of these cytokines. Am. J. Hematol. 89:E223\u2013E227, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23838","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T07:05:18Z","timestamp":1409209518000},"source":"Crossref","is-referenced-by-count":31,"title":["Elevated soluble <scp>IL<\/scp>\u20102<scp>R<\/scp>\u03b1, <scp>IL<\/scp>\u20108, and <scp>MIP<\/scp>\u20101\u03b2 levels are associated with inferior outcome and are independent of <scp>MIPI<\/scp> score in patients with mantle cell lymphoma"],"prefix":"10.1002","volume":"89","author":[{"given":"Mohamad B.","family":"Sonbol","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"Stenson","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine","family":"Allmer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy R.","family":"LaPlant","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa College of Medicine Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Macon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Witzig","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61272"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.2466"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61763-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70582-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.20.2337"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-5323(02)00127-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.07.014"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9560-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-1237"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0037"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22119"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.08.028"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.6674"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.226"},{"key":"e_1_2_5_16_1","first-page":"95","article-title":"Design and validity of a clinic\u2010based case\u2010control study on the molecular epidemiology of lymphoma","volume":"2","author":"Cerhan JR","year":"2011","journal-title":"Int J Mol Epidemiol Genet"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23259"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.2835"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306220"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03308.x"},{"key":"e_1_2_5_21_1","first-page":"1089","article-title":"Constitutive secretion of soluble interleukin\u20102 receptor by human T cell lymphoma xenografted into SCID mice. 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