{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:01:52Z","timestamp":1791273712684,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>This phase II trial evaluated efficacy and tolerability of R\u2010CHOP for up to 8 courses in Richter transformation (RT) and up to 6 courses in CLL plus autoimmune cytopenia (AIC) or high\u2010risk (HR) features. HR was defined as fludarabine\u2010refractoriness or early relapse (&lt;36 months) after fludarabine\u2010based treatment; 26 patients were included as HR, 19 patients had AIC, and 15 patients had RT. In the HR cohort, overall response rate was 54%, progression\u2010free and overall survival were 9 and 21 months. In AIC patients overall response rate was 74%, progression\u2010free and overall\u2010survival were 10 and 41 months, respectively, and median increase in hemoglobin was 3.4 g\/L. RT patients responded in 67%, progression\u2010free was 10 and overall survival 21 months. The most common adverse events were hematologic toxicities in 92%. Severe infections occurred in 28%. Treatment was discontinued early in 45% of all patients mainly as a result of toxicity. This trial shows that R\u2010CHOP has no role in treating complicated CLL. R\u2010CHOP is associated with significant toxicities and fairly low efficacy compared with almost every other CLL\u2010regimen. 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Hematol. 89:E239\u2013E243, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23841","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T05:49:22Z","timestamp":1409896162000},"source":"Crossref","is-referenced-by-count":107,"title":["Poor efficacy and tolerability of\n                    <scp>R\u2010CHOP<\/scp>\n                    in relapsed\/refractory chronic lymphocytic leukemia and\n                    <scp>R<\/scp>\n                    ichter transformation"],"prefix":"10.1002","volume":"89","author":[{"given":"Petra","family":"Langerbeins","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine Center of Integrated Oncology (CIO), and CECAD\u2010Cluster of Excellence \u201cCellular Stress Responses in Aging\u2010Associated Diseases,\u201d University of Cologne  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