{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:53:24Z","timestamp":1789012404936,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Iron overload in \u03b2\u2010thalassemia major (TM) typically results in iron\u2010induced cardiomyopathy, liver disease, and endocrine complications. We examined the incidence and progression of endocrine disorders (hypothyroidism, diabetes, hypoparathyroidism, hypogonadism), growth and pubertal delay, and bone metabolism disease during long\u2010term deferasirox chelation therapy in a real clinical practice setting. We report a multicenter retrospective cohort study of 86 transfusion\u2010dependent patients with TM treated with once daily deferasirox for a median duration of 6.5 years, up to 10 years. No deaths or new cases of hypothyroidism or diabetes occurred. The incidence of new endocrine complications was 7% (<jats:italic>P<\/jats:italic>\u2009=\u20090.338, for change of prevalence from baseline to end of study) and included hypogonadism (<jats:italic>n<\/jats:italic>\u2009=\u20095) and hypoparathyroidism (<jats:italic>n<\/jats:italic>\u2009=\u20091). Among patients with hypothyroidism or diabetes at baseline, no significant change in thyroid parameters or insulin requirements were observed, respectively. Mean lumbar spine bone mineral density increased significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and the number of patients with lumbar spine osteoporosis significantly decreased (<jats:italic>P<\/jats:italic>\u2009=\u20090.022) irrespective of bisphosphonate therapy, hormonal replacement therapy, and calcium or vitamin D supplementation. There were no significant differences in the number of pediatric patients below the 5th centile for height between baseline and study completion. Six pregnancies occurred successfully, and four of them were spontaneous without ovarian stimulation. This is the first study evaluating endocrine function during the newest oral chelation therapy with deferasirox. A low rate of new endocrine disorders and a stabilization of those pre\u2010exisisting was observed in a real clinical practice setting. Am. J. Hematol. 89:1102\u20131106, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23844","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T09:56:54Z","timestamp":1409911014000},"page":"1102-1106","source":"Crossref","is-referenced-by-count":72,"title":["Endocrine function and bone disease during long\u2010term chelation therapy with deferasirox in patients with \u03b2\u2010thalassemia major"],"prefix":"10.1002","volume":"89","author":[{"given":"Maddalena","family":"Casale","sequence":"first","affiliation":[{"name":"Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Citarella","sequence":"additional","affiliation":[{"name":"Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica Second University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Filosa","sequence":"additional","affiliation":[{"name":"UOSD Centro per le Microcitemie, AORN Cardarelli Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"De Michele","sequence":"additional","affiliation":[{"name":"Medicina Immunotrasfusionale Ospedale San Giovanni di Dio e Ruggi d'Aragona Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Radiologia e Diagnostica per Immagini Ospedale S. 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