{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:13:16Z","timestamp":1791184396154,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"INSERM I2MC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Peripheral serotonin (5\u2010HT) has been involved in adverse cardiac remodeling and valve fibrosis. The peripheral levels of 5\u2010HT mainly depend on its release from activated platelets and degradation by monoamine oxidase A (MAO\u2010A). The SERAOPI study investigated the relationship between arterial serotoninergic system, degree of platelet activation and cardiac remodeling, in patients with aortic valve stenosis (AS). Thirty patients with severe AS and 15 control subjects underwent transthoracic echocardiography, radial, and aortic arterial blood sampling. Measurements of 5\u2010HT and its MAO\u2010A\u2010dependent degradation product, 5\u2010HIAA, were performed by HPLC. Arterial platelet activation was assessed by flow cytometry analysis of platelet surface expression of P\u2010selectin and activated integrin GPIIb\/IIIa. Activated platelets and arterial plasma 5\u2010HT increased in AS patients as compared to control subjects (P\u2010selectin 1.08\u2009\u00b1\u20090.2MFI vs. 0.49\u2009\u00b1\u20090.1MFI, <jats:italic>P<\/jats:italic>\u2009=\u20090.04; GPIIb\/IIIa 0.71\u2009\u00b1\u20090.1MFI vs. 0.35\u2009\u00b1\u20090.1MFI; <jats:italic>P<\/jats:italic>\u2009=\u20090.0015 and arterial plasma 5\u2010HT 11.55\u2009\u00b1\u20091.6 n<jats:italic>M<\/jats:italic> vs. 6.18\u2009\u00b1\u20090.7 n<jats:italic>M<\/jats:italic>, <jats:italic>P<\/jats:italic>\u2009=\u20090.028, respectively). Moreover, 5\u2010HT was strongly correlated to left ventricular hypertrophy assessed by echocardiography. The correlation was independent of cardiovascular risk comorbidities and others echocardiographic AS parameters. Finally, plasma 5\u2010HIAA increased in AS patients (74.64\u2009\u00b1\u20099.7 n<jats:italic>M<\/jats:italic> vs. 37.16\u2009\u00b1\u20094.1 n<jats:italic>M<\/jats:italic>; <jats:italic>P<\/jats:italic>\u2009=\u20090.0002) indicating a higher 5\u2010HT degradation rate by MAO\u2010A. Platelet activation, arterial circulating serotonin, and serotonin degradation increased in patients with AS. These observations suggest that the serotoninergic system may contribute to the pathogenesis of AS including valve fibrosis and adverse ventricular remodeling. Am. J. Hematol. 90:15\u201319, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23855","type":"journal-article","created":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T08:55:20Z","timestamp":1411203320000},"page":"15-19","source":"Crossref","is-referenced-by-count":39,"title":["Platelet activation and arterial peripheral serotonin turnover in cardiac remodeling associated to aortic stenosis"],"prefix":"10.1002","volume":"90","author":[{"given":"Charlotte","family":"Rouzaud\u2010Laborde","sequence":"first","affiliation":[{"name":"INSERM, I2MC, U1048 Toulouse, Team 6 and 11, Institut des Maladies M\u00e9taboliques et Cardiovasculaires 1 avenue Jean Poulh\u00e8s BP 84225 Toulouse Cedex 4 France"},{"name":"Department of Pharmacy University Hospital Toulouse, H\u00f4pital Paule de Viguier 330 Avenue de Grande\u2010Bretagne TSA 70034 Toulouse Cedex 9 France"},{"name":"Unit of Pharmacology, University Hospital Versailles, Service de Biologie M\u00e9dicale, Unit\u00e9 de Pharmacologie\u2010Toxicologie, H\u00f4pital A. 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