{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:46:16Z","timestamp":1790682376351,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81230013, 81400146, and 81300440"],"award-info":[{"award-number":["81230013, 81400146, and 81300440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing","doi-asserted-by":"crossref","award":["7122193"],"award-info":[{"award-number":["7122193"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Municipal Science and Technology Program","award":["Z141100000214011."],"award-info":[{"award-number":["Z141100000214011."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>We investigated the effects of granulocyte colony\u2010stimulating factor (G\u2010CSF) on monocytic (M), promyelocytic (P), and granulocytic (G) myeloid\u2010derived suppressor cells (MDSCs) both in bone marrow and peripheral blood of 20 healthy donors and the association of MDSCs subgroups with acute and chronic graft\u2010versus\u2010host disease (aGvHD\/cGvHD) in 62 patients who underwent haplo\u2010identical allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Patients who received a higher absolute counts of M\u2010MDSCs or P\u2010MDSCs exhibited lower incidence of grade II\u2013IV aGvHD (<jats:italic>P =<\/jats:italic> 0.001; <jats:italic>P =<\/jats:italic> 0.031) and extensive cGvHD (<jats:italic>P =<\/jats:italic> 0.011; <jats:italic>P =<\/jats:italic> 0.021). In the multivariate analysis, absolute counts of MDSCs in allografts emerged as independent factors that reduced the occurrence of grade II\u2013IV aGvHD (M\u2010MDSCs: HR = 0.087, 95% CI = 0.020\u20130.381, <jats:italic>P =<\/jats:italic> 0.001; P\u2010MDSCs: HR = 0.357, 95% CI = 0.139\u20130.922, <jats:italic>P =<\/jats:italic> 0.033) and extensive cGvHD (M\u2010MDSCs: HR = 0.196, 95% CI = 0.043\u20130.894, <jats:italic>P =<\/jats:italic> 0.035; P\u2010MDSCs: HR = 0.257, 95% CI = 0.070\u20130.942, <jats:italic>P =<\/jats:italic> 0.04). Delayed M\u2010MDSC reconstitution was associated with aGvHD onset. The 3\u2010year cumulative incidence of transplant related mortality and relapse, 3\u2010year probability of disease\u2010free survival, and overall survival did not differ significantly between these subgroups. Our results suggested that G\u2010CSF\u2010induced immune tolerance may be mediated by M\/P\u2010MDSCs in allo\u2010HSCT. Am. J. Hematol. 90:E9\u2013E16, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23865","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T07:52:18Z","timestamp":1412927538000},"source":"Crossref","is-referenced-by-count":73,"title":["Monocytic and promyelocytic myeloid\u2010derived suppressor cells may contribute to <scp>G<\/scp>\u2010<scp>CSF<\/scp>\u2010induced immune tolerance in haplo\u2010identical allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"90","author":[{"given":"Meng","family":"Lv","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Su","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute 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