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We analyzed demographics and baseline clinical status, operative details, and outcomes at 4, 24, and 52 weeks after surgery. Results were summarized as hematologic outcomes, short\u2010term adverse events (AEs) (\u226430 days after surgery), and long\u2010term AEs (31\u2013365 days after surgery). For children with hereditary spherocytosis, after surgery there was an increase in hemoglobin (baseline 10.1\u2009\u00b1\u20091.8 g\/dl, 52 week 12.8\u2009\u00b1\u20091.6 g\/dl; mean\u2009\u00b1\u2009SD), decrease in reticulocyte and bilirubin as well as control of symptoms. Children with sickle cell disease had control of clinical symptoms after surgery, but had no change in hematologic parameters. There was an 11% rate of short\u2010term AEs and 11% rate of long\u2010term AEs. As we accumulate more subjects and longer follow\u2010up, use of a patient registry should enhance our capacity for clinical trials and engage all stakeholders in the decision\u2010making process. Am. J. Hematol. 90:187\u2013192, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23888","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T09:08:08Z","timestamp":1415610488000},"page":"187-192","source":"Crossref","is-referenced-by-count":36,"title":["Clinical outcomes of splenectomy in children: Report of the splenectomy in congenital hemolytic anemia registry"],"prefix":"10.1002","volume":"90","author":[{"given":"Henry E.","family":"Rice","sequence":"first","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Englum","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Rothman","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Leonard","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audra","family":"Reiter","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Brindle","sequence":"additional","affiliation":[{"name":"Alberta Children's Hospital Calgary AB"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Wright","sequence":"additional","affiliation":[{"name":"Alberta Children's Hospital Calgary AB"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.","family":"Heeney","sequence":"additional","affiliation":[{"name":"Children's Hospital of Boston Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Smithers","sequence":"additional","affiliation":[{"name":"Children's Hospital of Boston Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeccah L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodosia","family":"Kalfa","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob C.","family":"Langer","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children Toronto Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Cada","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children Toronto Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith T.","family":"Oldham","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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