{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:04:17Z","timestamp":1791180257185,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les Hepatites Virales","doi-asserted-by":"publisher","award":["Lympho-C HC 13"],"award-info":[{"award-number":["Lympho-C HC 13"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Hepatitis C virus (HCV) infection increases the risk of B\u2010cell non\u2010Hodgkin lymphomas (B\u2010NHL). Antiviral treatment (AT) can induce hematological responses in patients with marginal zone lymphomas (MZL). The ANRS HC\u201013 Lympho\u2010C study aimed at a better understanding of the impact of AT on HCV associated B\u2010NHL. This multicentric study enrolled 116 HCV\u2010positive patients with B\u2010NHL between 2006 and 2012. Cytological and histological samples were collected for centralized review. At lymphoma diagnosis, median age was 61 years and gender ratio M\/F was 1. Cytohistological distribution was marginal zone lymphoma (MZL) <jats:italic>n<\/jats:italic>\u2009=\u200945 (39%), diffuse large B\u2010cell lymphoma (DLBCL) <jats:italic>n<\/jats:italic>\u2009=\u200945 (39%), and other types <jats:italic>n<\/jats:italic>\u2009=\u200926 (22%). MZL patients had more frequent detection of rheumatoid factor (68% vs. 35%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and more frequently mixed cryoglobulinemia (74% vs. 44%; <jats:italic>P<\/jats:italic>\u2009=\u20090.021) than patients with DLBCL. Among patients receiving AT, a sustained virologic response was achieved in 23 of 38 (61%) patients with MZL and in 9 of 17 (53%) with DLBCL (P\u2009=\u20090.42). Three\u2010year overall survival (OS) and progression\u2010free survival were 78% 95%CI [63\u201388] and 64% [48\u201376], respectively, without difference between cytohistological groups. Outcome analysis showed a favorable association between OS and AT in all patients (P\u2009=\u20090.05) and in the subgroup of MZL patients only (P\u2009=\u20090.04). Our data support that AT improves the outcomes of HCV\u2010associated NHLs. The impact of new AT regimen with protease inhibitor needs to be investigated in this setting. <jats:bold>[<\/jats:bold><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicalTrials.gov\">clinicalTrials.gov<\/jats:ext-link> <jats:bold>Identification number NCT01545544]<\/jats:bold> Am. J. Hematol. 90:197\u2013203, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23889","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T17:56:27Z","timestamp":1416592587000},"page":"197-203","source":"Crossref","is-referenced-by-count":80,"title":["Antiviral therapy is associated with a better survival in patients with hepatitis C virus and B\u2010cell non\u2010Hodgkin lymphomas, ANRS HC\u201013 lympho\u2010C study"],"prefix":"10.1002","volume":"90","author":[{"given":"Jean\u2010Marie","family":"Michot","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Paris Sud University AP\u2010HP, H\u00f4pital Bic\u00eatre Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Canioni","sequence":"additional","affiliation":[{"name":"Department of Pathology Paris 5 Descartes University AP\u2010HP, H\u00f4pital Necker Paris 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Hematology Paris 5 Descartes University AP\u2010HP, H\u00f4pital Necker Paris France"},{"name":"Imagine Institute Universit\u00e9 Sorbonne Paris Cit\u00e9 INSERM U 1163, CNRS ERL 8254 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sibon","sequence":"additional","affiliation":[{"name":"Department of Adult Hematology Paris 5 Descartes University AP\u2010HP, H\u00f4pital Necker Paris France"},{"name":"Imagine Institute Universit\u00e9 Sorbonne Paris Cit\u00e9 INSERM U 1163, CNRS ERL 8254 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Thieblemont","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9mato\u2010oncologie Universit\u00e9 Paris Sorbonne P7 INSERM U728, AP\u2010HP, H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehan","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Department of Lymphoid 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