{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:02:57Z","timestamp":1770526977473,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>High\u2010dose chemotherapy with autologous stem cell transplantation (ASCT) has been shown effective in the control of relapsed\/refractory follicular lymphoma. We evaluate the long\u2010term outcome of patients with relapsed or refractory follicular lymphoma treated with ASCT with <jats:italic>in vivo<\/jats:italic> purged progenitors cells. We report the long\u2010term results of a prospective multicenter phase 2 trial on 124 relapsed\/refractory follicular lymphoma patients treated with a program of anthracycline\u2010based debulking chemotherapy, immunochemotherapy, mobilization of <jats:italic>in vivo<\/jats:italic> purged PBSC followed by ASCT. Median age was 52 years; 14% of patients had grade 3A histology. Debulking chemotherapy produced CR in 16% and PR in 71%, while 13% of patients progressed. After rituximab, cyclophosphamide, vincristine, prednisone (R\u2010COP), CR was obtained in 60% and PR in 35%; 118 patients successfully mobilized PBSC and 117 proceeded to ASCT. The harvest in all the 32 molecularly informative patients was bcl\u20102 negative. TRM was 0%. The 5\u2010year PFS was 54% and the 5\u2010year OS was 83%. After a median f\u2010up of 6.7 years (range 1.5\u201313.6), 54% are still in CR. These data show that prolonged PFS is achievable in relapsed\/refractory patients with high dose autologous transplantation of <jats:italic>in vivo<\/jats:italic> purged progenitor cells. Am. J. Hematol. 90:230\u2013234, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23919","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T08:51:19Z","timestamp":1418287879000},"page":"230-234","source":"Crossref","is-referenced-by-count":8,"title":["Autologous stem cell transplantation with <i>in vivo<\/i> purged progenitor cells shows long\u2010term efficacy in relapsed\/refractory follicular lymphoma"],"prefix":"10.1002","volume":"90","author":[{"given":"Luca","family":"Arcaini","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine University of Pavia Pavia Italy"},{"name":"Department of Hematology and Oncology Fondazione Istituto Di Ricovero E Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Morello","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia 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