{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:14:20Z","timestamp":1789013660708,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Epidemiological and Clinical Research Information Network (ECRIN)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>To investigate the factors that affect molecular responses on dasatinib treatment in patients with chronic\u2010phase chronic myeloid leukemia (CML\u2010CP), we performed a clinical trial named the \u201cD\u2010First study.\u201d Fifty\u2010two patients with newly diagnosed CML\u2010CP were enrolled in this study and received 100 mg dasatinib once daily. A deep molecular response (DMR) was defined as &lt;50 copies\/\u03bcg RNA of <jats:italic>BCR\u2010ABL1<\/jats:italic> transcript value corrected by <jats:italic>GAPDH<\/jats:italic>, which ensures &lt;0.01% of <jats:italic>BCR\u2010ABL1<\/jats:italic> transcript value according to International Scale (<jats:italic>BCR\u2010ABL1<jats:sup>IS<\/jats:sup><\/jats:italic>). The halving time for <jats:italic>BCR\u2010ABL1<\/jats:italic> transcripts was calculated using transcript levels before dasatinib treatment, transcript levels after 3 months of treatment, and the treatment time between these two points. In terms of molecular response, 38 of 51 (75%) patients reached major molecular response (MMR) by 12 months, and the rate of DMR by 18 months was 59% (30\/51). While both <jats:italic>BCR\u2010ABL1<\/jats:italic> transcript levels before treatment and a shorter halving time of <jats:italic>BCR\u2010ABL1<\/jats:italic> transcripts (\u226414 days) were significant factors affecting achievement of MMR by 12 months, the Sokal score at diagnosis was not associated with MMR. Importantly, the halving time was the only factor that predicted achievement of DMR by 18 months. We showed that patients with CML\u2010CP treated with dasatinib can be stratified according to the early treatment response as determined by the halving time of <jats:italic>BCR\u2010ABL1<\/jats:italic> transcripts. These data emphasize the significance of the early response from dasatinib treatment in achieving a DMR. (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>; NCT01464411) Am. J. Hematol. 90:282\u2013287, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23923","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T09:08:15Z","timestamp":1419239295000},"page":"282-287","source":"Crossref","is-referenced-by-count":43,"title":["Shorter halving time of BCR\u2010ABL1 transcripts is a novel predictor for achievement of molecular responses in newly diagnosed chronic\u2010phase chronic myeloid leukemia treated with dasatinib: Results of the D\u2010first study of <scp>K<\/scp>anto CML study group"],"prefix":"10.1002","volume":"90","author":[{"given":"Noriyoshi","family":"Iriyama","sequence":"first","affiliation":[{"name":"Division of Hematology and Rheumatology Department of Medicine Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikashi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Hematology National Hospital Organization Mito Medical Center  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Wakita","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Japanese Red Cross Society, Narita Red Cross Hospital Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Hematology Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine Keio University School of Medicine  Tokyo 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