{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:58:28Z","timestamp":1791907108109,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Many drugs have been reported to cause thrombotic microangiopathy (TMA), often described as thrombotic thrombocytopenic purpura (TTP) or hemolytic\u2010uremic syndrome (HUS). We recently established criteria to evaluate the evidence for a causal association of a drug with TMA and then we systematically reviewed all published reports of drug\u2010induced TMA (DITMA) to determine the level of evidence supporting a causal association of the suspected drug with TMA. On the basis of this experience, we used these evaluation criteria to assess the Oklahoma TTP\u2010HUS Registry patients who had been previously categorized as drug\u2010induced, 1989\u20132014. We also reviewed the experience of the BloodCenter of Wisconsin with testing for drug\u2010dependent antibodies reactive with platelets and neutrophils in patients with suspected immune\u2010mediated DITMA, 1988\u20132014. Among 58 patients in the Oklahoma Registry previously categorized as drug\u2010induced (15 suspected drugs), 21 patients (three drugs: gemcitabine, pentostatin, quinine) had evidence supporting a definite association with TMA; 19 (90%) of the 21 patients had quinine\u2010induced TMA. The BloodCenter of Wisconsin tested 40 patients with suspected DITMA (eight drugs); drug\u2010dependent antibodies, supporting a definite association with TMA, were identified in 30 patients (three drugs: oxaliplatin, quinine, vancomycin); 28 (93%) of the 30 patients had quinine\u2010induced TMA. Combining the data from these two sources, 51 patients (five drugs) have been identified with evidence supporting a definite association with TMA. DITMA was attributed to quinine in 47 (92%) of these 51 patients. Am. J. Hematol. 90:406\u2013410, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23960","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T12:23:13Z","timestamp":1422620593000},"page":"406-410","source":"Crossref","is-referenced-by-count":113,"title":["<scp>D<\/scp>rug\u2010induced thrombotic microangiopathy: <scp>E<\/scp>xperience of the <scp>O<\/scp>klahoma registry and the BloodCenter of <scp>W<\/scp>isconsin"],"prefix":"10.1002","volume":"90","author":[{"given":"Jessica A.","family":"Reese","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Epidemiology College of Public Health, University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Bougie","sequence":"additional","affiliation":[{"name":"Department of Medicine Medical College of Wisconsin and, Blood Research Institute, BloodCenter of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Medicine Medical College of Wisconsin and, Blood Research Institute, BloodCenter of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdra R","family":"Terrell","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology College of Public Health, University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara K.","family":"Vesely","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology College of Public Health, University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Aster","sequence":"additional","affiliation":[{"name":"Department of Medicine Medical College of Wisconsin and, Blood Research Institute, BloodCenter of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology College of Public Health, University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"},{"name":"Hematology\u2013Oncology Section Department of Medicine College of Medicine, University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1312353"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02799-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","unstructured":"Al\u2010NouriZL ReeseJA TerrellDR et al.Drug\u2010induced thrombotic microangiopathy: A systematic review of published reports.Blood2015;125:616\u2013618.","DOI":"10.1182\/blood-2014-11-611335"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0193"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-276691"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.12.3846"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199908)61:4<268::AID-AJH9>3.0.CO;2-O"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-12-200112180-00008"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830470407"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-11_Part_1-199812010-00009"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra066469"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24612"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740330902942299"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1940.72810420002011a"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10148"},{"key":"e_1_2_5_17_1","first-page":"519","article-title":"Occult quinine\u2010induced thrombocytopenia","volume":"93","author":"Kojouri K","year":"2000","journal-title":"J Okla State Med Assoc"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.2.218"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200312000-00015"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)93309-D"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70321-0"},{"key":"e_1_2_5_22_1","unstructured":"MarderE KirschkeD RobbinsD et al. 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