{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:53:15Z","timestamp":1791193995063,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Colony stimulating factor 3 receptor gene (<jats:italic>CSF3R<\/jats:italic>) mutations have recently been associated with chronic neutrophilic leukemia (CNL). Fourteen patients with <jats:italic>CSF3R<\/jats:italic>\u2010mutated CNL (median age 67 years; 57% males) were screened for additional mutations; 8 (57%) and 5 (38%) harbored an <jats:italic>ASXL1<\/jats:italic> and\/or <jats:italic>SETBP1<\/jats:italic> mutation (two patients expressed both), respectively. Two patients developed blastic transformation, both <jats:italic>SETBP1\u2010<\/jats:italic>mutated and <jats:italic>ASXL1\u2010<\/jats:italic>unmutated, whereas two other cases evolved into chronic myelomonocytic leukemia (CMML), both <jats:italic>ASXL1<\/jats:italic>\u2010mutated and <jats:italic>SETBP1\u2010<\/jats:italic>unmutated. Median survival was 23.2 months (10 deaths documented). On multivariable analysis mutated <jats:italic>ASXL1<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009=\u20090.009; HR 19.6, 95% CI 2.1\u2013184.1) and thrombocytopenia (<jats:italic>P<\/jats:italic>\u2009=\u20090.005; HR 28.8, 95% CI 2.8\u2013298.2) were independently predictive of shortened survival. This study provides information on the natural history of <jats:italic>CSF3R<\/jats:italic>\u2010mutated CNL and identifies mutant <jats:italic>ASXL1<\/jats:italic> and thrombocytopenia as risk factors for survival. The study also suggests pathogenetic roles for <jats:italic>SETBP1<\/jats:italic> and <jats:italic>ASXL1<\/jats:italic> mutations in disease evolution into blast phase disease and CMML, respectively. Am. J. Hematol. 90:653\u2013656, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24031","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T07:39:17Z","timestamp":1428478757000},"page":"653-656","source":"Crossref","is-referenced-by-count":87,"title":["<i>ASXL1<\/i> mutations are frequent and prognostically detrimental in <i>CSF3R<\/i>\u2010mutated chronic neutrophilic leukemia"],"prefix":"10.1002","volume":"90","author":[{"given":"Michelle A.","family":"Elliott","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Animesh","family":"Pardanani","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis 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