{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:33:23Z","timestamp":1778776403427,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL117659; R01HL111659; UL1TR001111"],"award-info":[{"award-number":["U01HL117659; R01HL111659; UL1TR001111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Red blood cell (RBC) alloimmunization is a significant clinical complication of sickle cell disease (SCD). It can lead to difficulty with cross\u2010matching for future transfusions and may sometimes trigger life\u2010threatening delayed hemolytic transfusion reactions. We conducted a retrospective study to explore the association of clinical complications and age of RBC with alloimmunization in patients with SCD followed at a single institution from 2005 to 2012. One hundred and sixty six patients with a total of 488 RBC transfusions were evaluated. Nineteen patients (11%) developed new alloantibodies following blood transfusions during the period of review. The median age of RBC units was 20 days (interquartile range: 14\u201327 days). RBC antibody formation was significantly associated with the age of RBC units (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), with a hazard ratio of 3.5 (95% CI: 1.71\u20137.11) for a RBC unit that was 7 days old and 9.8 (95% CI: 2.66\u201335.97) for a unit that was 35 days old, 28 days after the blood transfusion. No association was observed between RBC alloimmunization and acute vaso\u2010occlusive complications. Although increased echocardiography\u2010derived tricuspid regurgitant jet velocity (TRV) was associated with the presence of RBC alloantibodies (<jats:italic>P<\/jats:italic>\u2009=\u20090.02), TRV was not significantly associated with alloimmunization when adjusted for patient age and number of transfused RBC units. Our study suggests that RBC antibody formation is significantly associated with older age of RBCs at the time of transfusion. Prospective studies in patients with SCD are required to confirm this finding. Am. J. Hematol. 90:691\u2013695, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24051","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T21:16:29Z","timestamp":1431378989000},"page":"691-695","source":"Crossref","is-referenced-by-count":51,"title":["Alloimmunization is associated with older age of transfused red blood cells in sickle cell disease"],"prefix":"10.1002","volume":"90","author":[{"given":"Payal C.","family":"Desai","sequence":"first","affiliation":[{"name":"Division of Hematology The Ohio State University Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison M.","family":"Deal","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center Biostatistics Core Facility University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R.","family":"Pfaff","sequence":"additional","affiliation":[{"name":"NC TraCS Institute, University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahjat","family":"Qaqish","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center Biostatistics Core Facility University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyna M.","family":"Hebden","sequence":"additional","affiliation":[{"name":"Department of Hospital Labs Transfusion Medicine Services, University of North Carolina Healthcare"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara A.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth I.","family":"Ataga","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology University of North Carolina at Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2002.00396.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90193-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1142\/9781860947964_0008"},{"key":"e_1_2_6_5_1","first-page":"274","article-title":"Prophylactic transfusions in pregnant patients with sickle hemoglobinopathies: Benefit versus risk","volume":"56","author":"Morrison JC","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_1","first-page":"51","article-title":"Chronic transfusions in patients with sickle cell disease. Indications and problems","volume":"7","author":"Piomelli S","year":"1985","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.7.1431.1431"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830050204"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02819.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(01)90054-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222301"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490623"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01433.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00946.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00708.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328313695e"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1998.tb01060.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020523000109"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2760"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20196"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10726"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-327361"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1537-2995.2009.02481.x","article-title":"Immunohematology: Storage of murine red blood cells enhances alloantibody responses to an erythroid\u2010specific model antigen","volume":"50","author":"Hendrickson JE","journal-title":"Transfusion"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22167"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-327361"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1182\/blood-2009-10-245001","article-title":"Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation","volume":"115","author":"Hod EA","journal-title":"Blood"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1537-2995.2010.02861.x","article-title":"Red blood cell microparticles show altered inflammatory chemokine binding and release ligand upon interaction with platelets","volume":"51","author":"Xiong Z","journal-title":"Transfusion"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/CIRCULATIONAHA.110.008698","article-title":"Nitric oxide scavenging by red blood cell microparticles and Cell\u2010free hemoglobin as a mechanism for the red cell storage lesion\/clinical perspective","volume":"124","author":"Donadee C","journal-title":"Circulation"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1202-799"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","unstructured":"LocatelliF KabbaraN RuggeriA et al. Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA\u2010identical sibling. Blood2013;122:1072\u20131078.","DOI":"10.1182\/blood-2013-03-489112"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-3-2"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10142"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.5.1555"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.2.214.214"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-361642"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.6.2311.bloodjournal8862311"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.24051","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.24051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:02:27Z","timestamp":1695560547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.24051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,28]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/ajh.24051"],"URL":"https:\/\/doi.org\/10.1002\/ajh.24051","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,28]]}}}