{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:03:35Z","timestamp":1792627415981,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CCSG","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>The pathophysiology of <jats:italic>IDH<\/jats:italic> mutations in tumorigenesis is increasingly described, yet the prognostic significance of <jats:italic>IDH1<\/jats:italic> and <jats:italic>IDH2<\/jats:italic> mutations in AML remains controversial. The primary objective of this study was to define the natural history and prognosis of patients with AML and <jats:italic>IDH1<\/jats:italic> or <jats:italic>IDH2<\/jats:italic> mutations and provide historical survival expectations. A total of 826 patients treated from 2010 to 2014 at a single institution were evaluated, including 167 patients (20%) with AML and <jats:italic>IDH1<\/jats:italic> or <jats:italic>IDH2<\/jats:italic> mutations. Median age was 62 years (range 18\u201392). There were 59 <jats:italic>IDH1<\/jats:italic>\u2010R132, 83 <jats:italic>IDH2<\/jats:italic>\u2010R140, and 23 <jats:italic>IDH2<\/jats:italic>\u2010R172 mutations. Clinicopathologic characteristics associated with <jats:italic>IDH<\/jats:italic>\u2010mutations included older age, less frequent therapy\u2010related status, and increased incidence of intermediate\u2010risk cytogenetics, <jats:italic>FLT3\u2010ITD<\/jats:italic> mutations, and <jats:italic>NPM1<\/jats:italic> mutations. Remission rates (CR\/CRi) by AML treatment status were: induction, 68%; Salvage\u20101 (S1), 42%; and Salvage\u20102 and beyond (S2+), 27%. No difference in response was identified by <jats:italic>IDH<\/jats:italic> mutation status. Similarly, overall survival (OS) was not dependent on <jats:italic>IDH<\/jats:italic> status within any cohort. The median OS was 15.4 months in induction, 8.7 months in S1, and 4.8 months in S2+. This analysis defines the clinical outcome associated with <jats:italic>IDH<\/jats:italic>\u2010mutations in both the front\u2010line and salvage AML treatment settings, and confirms that response rate and OS for both <jats:italic>IDH<\/jats:italic>\u2010mutated and <jats:italic>IDH<\/jats:italic> wild\u2010type AML patients is comparable. This provides contemporary data to be used for comparison with results of novel investigational (e.g., selective <jats:italic>IDH<\/jats:italic> inhibitor) strategies. Am. J. Hematol. 90:732\u2013736, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24072","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T03:10:46Z","timestamp":1432782646000},"page":"732-736","source":"Crossref","is-referenced-by-count":298,"title":["Characteristics, clinical outcome, and prognostic significance of <scp>IDH<\/scp> mutations in <scp>AML<\/scp>"],"prefix":"10.1002","volume":"90","author":[{"given":"Courtney D.","family":"DiNardo","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Ravandi","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston 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