{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:33:22Z","timestamp":1791344002233,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T00:00:00Z","timestamp":1439510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Karyotypic abnormalities are detected in 20\u201340% of chronic myelomonocytic leukemia (CMML) patients at initial diagnosis and have been shown to correlate with patients' outcome. The significance of acquisition of cytogenetic abnormalities (ACA) during the course of CMML, however, is largely unknown. In a cohort of 314 CMML patients, karyotypic abnormalities were detected in 106 (34%) patients at the time of diagnosis; and ACA were detected in 80 (25%) patients after a median interval of 17 months (range, 2\u2013117 months). The most frequently observed ACA were a complex karyotype, followed by +21, \u22127\/del(7q), del(20q), i(17q), and \u221217\/del(17p). ACA appeared to occur more frequently in patients with a normal or lower risk karyotype. Progression to AML was seen in 44 of 80 (55%) patients with ACA versus 67 of 234 (29%) patients without ACA (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Presence of ACA predicted an inferior leukemia\u2010free survival (LFS) by univariate (<jats:italic>P<\/jats:italic>\u2009=\u20090.0435) and multivariate analysis (HR\u2009=\u20091.892, <jats:italic>P<\/jats:italic>\u2009=\u20090.006). While acquisition of a complex karyotype was positively correlated with AML progression (<jats:italic>P<\/jats:italic>\u2009=\u20090.0086), del(20q) was associated with a stable disease (<jats:italic>P<\/jats:italic>\u2009=\u20090.0198). We conclude that ACA occur in \u223c20\u201330% of CMML patients during the course of disease, and are significantly associated with AML progression and a shorter LFS. Karyotypic abnormalities, either present at diagnosis or acquired during the course of disease, have prognostic implication in CMML patients. Am. J. Hematol. 90:882\u2013887, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24108","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T07:51:01Z","timestamp":1436169061000},"page":"882-887","source":"Crossref","is-referenced-by-count":16,"title":["Prognostic impact of acquisition of cytogenetic abnormalities during the course of chronic myelomonocytic leukemia"],"prefix":"10.1002","volume":"90","author":[{"given":"Guilin","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kausar","family":"Jabbar","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa A.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23751"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.840"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01868.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0977-1"},{"key":"e_1_2_6_6_1","first-page":"1168","article-title":"Identification of novel cytogenetic markers with prognostic significance in a series of 968 patients with primary myelodysplastic syndromes","volume":"90","author":"Sole F","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-082404"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.030957"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-452938"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.3314"},{"key":"e_1_2_6_11_1","first-page":";4:e270.","article-title":"Chronic myelomonocytic leukemia in younger patients: Molecular and cytogenetic predictors of survival and treatment outcome","author":"Patnaik MM","year":"2015","journal-title":"Blood Cancer J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23846"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2790"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23513"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2009.09.015"},{"key":"e_1_2_6_16_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_6_17_1","volume-title":"An international system for human cytogenetic nomenclature (ISCN)","author":"Shaffer LG","year":"2013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb04173.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00021-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819042000207271"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.88"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23574"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.1361"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23962"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.24108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.24108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:26:49Z","timestamp":1695504409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.24108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,14]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/ajh.24108"],"URL":"https:\/\/doi.org\/10.1002\/ajh.24108","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,14]]}}}