{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:29:20Z","timestamp":1784946560049,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>The importance of allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) for survival outcomes in patients with acute myeloid leukemia (AML) currently remains unclear. The study aimed to compare measures of clinical treatment for patients with AML in CR1 (the first complete remission) with or without being subjected to allo\u2010HSCT. These consisted of leukemia\u2010free survival (LFS), overall survival (OS), cumulative incidence of relapse (CIR), and non\u2010relapse mortality disease (NRM). Subjects were 622 patients, median age of 44, forming part of the prospective, randomized, and multicenter clinical Polish Adult Leukemia Group trials during 1999\u20132008. The Mantel\u2013Byar approach was used to assess allo\u2010HSCT on survival endpoints, accounting for a changing transplant status. Undergoing allo\u2010HSCT significantly improved the LFS and OS for the entire group of patients with AML in CR1, along with the DAC induction subgroup and for the group with unfavorable cytogenetics aged 41\u201360. The CIR demonstrated that allo\u2010HSCT reduced the risk of relapse for patients with AML in CR1 and those with an unfavorable cytogenetic risk. In addition, the NRM analysis showed that allo\u2010HSCT significantly reduced the risk of death unrelated to relapse for the entire group of AML patients in CR1 and aged 41\u201360. The allo\u2010HSCT treatment particularly benefitted survival for the AML in CR1 group having an unfavorable cytogenetic prognosis.  Am. J. Hematol. 90:904\u2013909, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24113","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T23:19:05Z","timestamp":1436224745000},"page":"904-909","source":"Crossref","is-referenced-by-count":7,"title":["Assessing the efficacy of allogeneic hematopoietic stem cells transplantation (allo\u2010<scp>HSCT<\/scp>) by analyzing survival end points in defined groups of acute myeloid leukemia patients: A retrospective, multicenter <scp>P<\/scp>olish <scp>A<\/scp>dult <scp>L<\/scp>eukemia <scp>G<\/scp>roup study"],"prefix":"10.1002","volume":"90","author":[{"given":"Sebastian","family":"Grosicki","sequence":"first","affiliation":[{"name":"Department of Cancer Prevention, School of Public Health Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Holowiecki","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation, Branch Gliwice Comprehensive Cancer Center M. 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