{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:47:32Z","timestamp":1790740052140,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T00:00:00Z","timestamp":1439510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Herta Christensen Foundation, Aalborg, 2012"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>According to the updated guidelines for imaging in lymphoma, 18F\u2010FDG positron emission tomography\/computed tomography (PET\/CT) is recommended for staging and evaluation of treatment response in FDG\u2010avid lymphomas. The purpose of the study was to evaluate the utility of PET\/CT in nodal peripheral T\u2010cell lymphomas (PTCL). Patients with newly diagnosed nodal PTCL (peripheral T\u2010cell lymphoma NOS, anaplastic large\u2010cell lymphoma, or angioimmunoblastic T\u2010cell lymphoma) seen at five Danish hematology centers during the period 2006 to 2012 were included, if they had been pretherapeutically staged with PET\/CT. Medical records were reviewed for baseline clinical and follow\u2010up information. Staging, interim (I\u2010PET), and end\u2010of\u2010treatment PET\/CT (E\u2010PET) studies were centrally reviewed, and reported using the Deauville 5\u2010point score (DS). A total of 124 patients fulfilled the inclusion criteria. The median age was 58 years, and 88% received CHOP\/CHOP\u2010like therapy. Five years PFS and OS of the study population was 36.8% (95% CI 27.3\u201346.4) and 49.7% (95% CI 38.9\u201359.6), respectively. The presence of PET\/CT\u2010ascertained lung and\/or liver involvement was associated with a worse outcome. The sensitivity of PET\/CT for detecting biopsy\u2010defined bone marrow involvement was only 18% (95% CI 4\u201343). An interim DS &gt;3 was not prognostic for worse OS and PFS among CHOP\/CHOP\u2010like treated patients in uni\u2010 or multivariate analyses. A DS &gt;3 after treatment predicted a worse prognosis. In conclusion, I\u2010PET was not predictive of outcome in CHOP\/CHOP\u2010like treated PTCL patients when using the DS. Prospective studies are needed to determine the optimal use of PET\/CT in PTCL including the role of quantitative PET\/CT analysis. Am. J. Hematol. 90:975\u2013980, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24128","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T23:27:21Z","timestamp":1437607641000},"page":"975-980","source":"Crossref","is-referenced-by-count":57,"title":["Utility of interim and end\u2010of\u2010treatment PET\/CT in peripheral T\u2010cell lymphomas: A review of 124 patients"],"prefix":"10.1002","volume":"90","author":[{"given":"Tarec Christoffer","family":"El\u2010Galaly","sequence":"first","affiliation":[{"name":"Department of Hematology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Bjerreg\u00e5rd","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Department of Hematology Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Juul","family":"Mylam","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Ortved","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Hematology Herlev Hospital, Copenhagen University Hospital  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"B\u00f8gsted","sequence":"additional","affiliation":[{"name":"Department of Hematology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"de Nully Brown","sequence":"additional","affiliation":[{"name":"Department of Hematology Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Loft","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Nuclear Medicine and PET, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Lerberg","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Westergreen","family":"Hendel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Herlev Hospital, Copenhagen University Hospital  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Christian","family":"Gormsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_6_3_1","first-page":"76","article-title":"Prognostic significance of T\u2010cell phenotype in aggressive non\u2010Hodgkin's lymphomas. 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