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The main purpose of the present study was to identify the possible risk factors for the occurrence and prognosis of post\u2010PV MF in Chinese patients with PV. A cohort of 272 Chinese PV patients with <jats:italic>JAK2<\/jats:italic><jats:sup>V617F<\/jats:sup> or exon12 mutation was retrospectively analyzed. Of the 272 patients with PV, 63 developed post\u2010PV MF. Platelet count &gt;550\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L and splenomegaly were identified as independent risk factors for post\u2010PV MF. The median duration of survival for post\u2010PV MF patients was 8 years. Anemia and age &gt;65 years at diagnosis of post\u2010PV MF were identified as significant predictors for the poor prognosis of post\u2010PV MF. In conclusion, platelet counts and splenomegaly were significant predictors for the transformation to post\u2010PV MF, while anemia (hemoglobin levels &lt;100 g\/L) and age&gt;65 years were significant predictors for poor prognosis of post\u2010PV MF in Chinese PV patients with <jats:italic>JAK2<\/jats:italic><jats:sup>V617F<\/jats:sup> or exon12 mutation. Am. J. Hematol. 90:1116\u20131121, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24191","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T08:18:19Z","timestamp":1442305099000},"page":"1116-1121","source":"Crossref","is-referenced-by-count":17,"title":["Incidence and risk factors for myelofibrotic transformation among 272 Chinese patients with JAK2\u2010mutated polycythemia vera"],"prefix":"10.1002","volume":"90","author":[{"given":"Jie","family":"Bai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Liaoning Medical University Jinzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Chun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Sylvester Comprehensive Cancer Center, University of Miami Leonard M. 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