{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:36:25Z","timestamp":1790289385663,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5R01HL098239"],"award-info":[{"award-number":["5R01HL098239"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Children with sickle cell anemia (SCA) and conditional transcranial Doppler (TCD) ultrasound velocities (170\u2013199 cm\/sec) may develop stroke. However, with limited available clinical data, the current standard of care for conditional TCD velocities is observation. The efficacy of hydroxyurea in preventing conversion from conditional to abnormal TCD (\u2265200 cm\/sec), which confers a higher stroke risk, has not been studied prospectively in a randomized trial. Sparing Conversion to Abnormal TCD Elevation (SCATE #NCT01531387) was a National Heart, Lung, and Blood Institute\u2010funded Phase III multicenter international clinical trial comparing alternative therapy (hydroxyurea) to standard care (observation) to prevent conversion from conditional to abnormal TCD velocity in children with SCA. SCATE enrolled 38 children from the United States, Jamaica, and Brazil [HbSS (36), HbS\u03b2<jats:sup>0<\/jats:sup>\u2010thalassemia (1), and HbSD (1), median age\u2009=\u20095.4 years (range, 2.7\u20139.8)]. Because of the slow patient accrual and administrative delays, SCATE was terminated early. In an intention\u2010to\u2010treat analysis, the cumulative incidence of abnormal conversion was 9% (95% CI\u2009=\u20090\u201335%) in the hydroxyurea arm and 47% (95% CI\u2009=\u20096\u201381%) in observation arm at 15 months (<jats:italic>P<\/jats:italic>\u2009=\u20090.16). In post hoc analysis according to treatment received, significantly fewer children on hydroxyurea converted to abnormal TCD velocities when compared with observation (0% vs. 50%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). After a mean of 10.1 months, a significant change in mean TCD velocity was observed with hydroxyurea treatment (\u221215.5 vs. +10.2 cm\/sec, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). No stroke events occurred in either arm. Hydroxyurea reduces TCD velocities in children with SCA and conditional velocities. Am. J. Hematol. 90:1099\u20131105, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24198","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T19:14:44Z","timestamp":1443467684000},"page":"1099-1105","source":"Crossref","is-referenced-by-count":68,"title":["Prevention of conversion to abnormal transcranial <scp>D<\/scp>oppler with hydroxyurea in sickle cell anemia: A <scp>P<\/scp>hase III international randomized clinical trial"],"prefix":"10.1002","volume":"90","author":[{"given":"Jane S.","family":"Hankins","sequence":"first","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"McCarville","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital Memphis 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