{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:48:15Z","timestamp":1791920895621,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T00:00:00Z","timestamp":1453420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>\n                    Human immunodeficiency virus (HIV)\u2010associated primary effusion lymphoma (PEL) is a rare B\u2010cell non\u2010Hodgkin lymphoma with poor prognosis. Lymphoma cells are always infected with human herpesvirus\u20108 (HHV\u20108) and in most cases coinfected with Epstein\u2010Barr virus. In classic presentation, PEL is characterized by body cavity effusions with or without mass lesions. A variant with only extracavitary localization has also been described. We report on a large single\u2010center series of patients with PEL in the era of combined antiretroviral therapy (cART). The main objective was to compare the characteristics and the outcome of patients with classic (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200934) and extracavitary (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200917) variant PEL. At PEL diagnosis, no major difference was observed between the two groups in terms of demographic and HIV characteristics. Extracavitary localizations were exclusively nodal in six patients and involved various organs in 11 patients. Another HHV\u20108\u2010associated disease was observed in 31 patients, Kaposi sarcoma in 25, and multicentric Castleman disease in 18 patients, without difference between the two groups. Thirty\u2010two patients were treated with CHOP associated with high\u2010dose methotrexate, 13 were treated with CHOP\u2010derived regimen alone, and six patients received low\u2010dose\/no chemotherapy. Complete remission was achieved in 21 (62%) and seven (41%) patients of the classic and extracavitary groups, respectively. The median overall survival (OS) was 10.2 months. Despite a higher disease\u2010free survival in the extracavitary group, there was no difference in OS between the two variants. Based on this series, characteristics of classic and extracavitary variants were very close. Although prognosis of PEL remains very severe in cART era, the median survival compares favorably with earlier series. Am. J. Hematol. 91:233\u2013237, 2016. \u00a9 2015 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.24251","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T04:34:53Z","timestamp":1448339693000},"page":"233-237","source":"Crossref","is-referenced-by-count":120,"title":["Classic and extracavitary primary effusion lymphoma in 51\n                    <scp>HIV<\/scp>\n                    \u2010infected patients from a single institution"],"prefix":"10.1002","volume":"91","author":[{"given":"St\u00e9phanie","family":"Guillet","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Saint\u2010Louis Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Saint\u2010Louis Hospital, AP\u2010HP Paris France"},{"name":"EA3518, University Paris Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Meignin","sequence":"additional","affiliation":[{"name":"EA3518, University Paris Diderot Paris France"},{"name":"Department of Pathology Saint\u2010Louis Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Agbalika","sequence":"additional","affiliation":[{"name":"EA3518, University Paris Diderot Paris France"},{"name":"Virology Laboratory, Saint\u2010Louis Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Cuccini","sequence":"additional","affiliation":[{"name":"Hematology Laboratory, Saint\u2010Louis Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Denis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Saint\u2010Louis Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Katlama","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Galicier","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Saint\u2010Louis Hospital, AP\u2010HP Paris France"},{"name":"EA3518, University Paris Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Oksenhendler","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Saint\u2010Louis Hospital, AP\u2010HP Paris France"},{"name":"EA3518, University Paris Diderot Paris 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