{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T06:33:29Z","timestamp":1781418809851,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mario Lemieux Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p><jats:italic>Clostridium difficile<\/jats:italic> infections (CDI) remain the leading cause of infectious diarrhea among hospitalized patients in this country. Patients with hematologic malignancies, especially those who undergo hematopoietic progenitor cell transplants are particularly at risk for developing CDI. One hundred and forty seven consecutive allogeneic hematopoietic progenitor cell transplants were analyzed for peri\u2010transplant <jats:italic>Clostridium difficile<\/jats:italic> infections (PT\u2010CDI). Sixteen patients (11%) developed PT\u2010CDI (Median time\u2009=\u20097 days after transplant). The probability for developing PT\u2010CDI during the peri\u2010transplant period was 12.3%. History of CDI was strongly associated with the development of PT\u2010CDI (<jats:italic>P<\/jats:italic>\u2009=\u20090.008) (OR\u2009=\u20095.48) (<jats:italic>P<\/jats:italic>\u2009=\u20090.017). These patients also developed PT\u2010CDI much earlier than in those without a history (median 1 day <jats:italic>vs<\/jats:italic>. 8 days, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). The probability for developing PT\u2010CDI for those with a history was 39%. There was a trend toward significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.065) between matched related donor grafts and the development of PT\u2010CDI (OR\u2009=\u20090.245) (<jats:italic>P<\/jats:italic>\u2009=\u20090.08). Age, sex, diagnosis, transplant preparative regimens, Graft\u2010versus\u2010host disease (GVHD) prophylaxis, grade 3\/4 acute GVHD, or use of antimicrobials within 8 weeks of transplant were not associated with PT\u2010CDI. Non\u2010CDI\u2010related deaths occurred in one patient in the PT\u2010CDI group and nine in the group without PT\u2010CDI. In the remaining 139 patients, the length of hospital stay for those with PT\u2010CDI was significantly longer than those without (mean 27 days <jats:italic>vs<\/jats:italic>. 22 days; <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Am. J. Hematol. 91:291\u2013294, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24263","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T00:55:16Z","timestamp":1449795316000},"page":"291-294","source":"Crossref","is-referenced-by-count":15,"title":["Peri\u2010transplant clostridium difficile infections in patients undergoing allogeneic hematopoietic progenitor cell transplant"],"prefix":"10.1002","volume":"91","author":[{"given":"Aya","family":"Agha","sequence":"first","affiliation":[{"name":"Hematologic Malignancy and Stem Cell Transplant Program University of Pittsburgh Medical Center Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Hematologic Malignancy and Stem Cell Transplant Program University of Pittsburgh Medical Center Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew 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