{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:58:19Z","timestamp":1792501099236,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>\n                    Spleen enlargement, present in 10\u201320% of Essential Thrombocythemia (ET) patients at diagnosis, is a feature clinically easy to assess, confirmable by echography with a very low chance of misinterpretation. Nonetheless, the clinical and prognostic role of splenomegaly has been seldom evaluated. From 1979 to 2013, 1297 ET patients retrospectively collected in the database of the Lazio Cooperative Group and Bologna University Hospital were evaluable for spleen enlargement at diagnosis and included in the analysis. On the whole, spleen was enlarged in 172\/1297 (13.0%) patients; in most cases (94.8%) splenomegaly was mild (\u22645 cm). Patients with splenomegaly were younger, predominantly male, presented higher platelet count and\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F allele burden and had a lower incidence of concomitant cardiovascular risk factors. At least one thrombotic event during follow\u2010up occurred in 97\/1,125 (8.6%) patients without spleen enlargement compared to 27\/172 (15.7%) patients with spleen enlargement (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.003). Despite comparable use of cytoreductive\/antiplatelet therapies in the two groups, the cumulative risk of thrombosis at 5 years was significantly higher in patients with baseline splenomegaly (9.8% versus 4.4% in patients without splenomegaly,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.012). In multivariate analysis exploring risk factors for thrombosis, splenomegaly retained its negative prognostic role, together with previous thrombosis, leucocyte count and male gender. Baseline splenomegaly seems to be an independent additional risk factor for thrombosis in nonstrictly WHO\u2010defined ET patients. This data could be useful in the real\u2010life clinical management of these patients. Am. J. Hematol. 91:318\u2013321, 2016. \u00a9 2016 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.24269","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T04:05:12Z","timestamp":1452398712000},"page":"318-321","source":"Crossref","is-referenced-by-count":31,"title":["Spleen enlargement is a risk factor for thrombosis in essential thrombocythemia: Evaluation on 1,297 patients"],"prefix":"10.1002","volume":"91","author":[{"given":"Alessandro","family":"Andriani","sequence":"first","affiliation":[{"name":"Division of Hematology Nuovo Regina Margherita Hospital Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Latagliata","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza\u201d Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Anaclerico","sequence":"additional","affiliation":[{"name":"San Giovanni Hospital Divison of Hematology Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Spadea","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit, Regina Elena National Cancer Institute, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Rago","sequence":"additional","affiliation":[{"name":"Division of Hematology Polo Universitario Pontino Latina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Di Veroli","sequence":"additional","affiliation":[{"name":"Division of Hematology University \u201cTor Vergata\u201d Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Spirito","sequence":"additional","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo\u2010Forlanini Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Porrini","sequence":"additional","affiliation":[{"name":"Division of Hematology Sant'andrea Hospital Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"De Muro","sequence":"additional","affiliation":[{"name":"Hematology, University \u201cCampus Biomedico\u201d Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Crescenzi Leonetti","sequence":"additional","affiliation":[{"name":"Division of Hematology SandroPertini Hospital Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Villiv\u00e0","sequence":"additional","affiliation":[{"name":"Division of Hematology Nuovo Regina Margherita Hospital Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"De Gregoris","sequence":"additional","affiliation":[{"name":"Hematology, Belcolle Hospital Viterbo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Montefusco","sequence":"additional","affiliation":[{"name":"Division of Hematology Sant'andrea Hospital Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Polverelli","sequence":"additional","affiliation":[{"name":"Institute of Hematology \u201cL. And a. Ser\u00e0gnoli\u201d, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, S. Orsola\u2010Malpighi Hospital  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza\u201d Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza\u201d Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cimino","sequence":"additional","affiliation":[{"name":"IFO-San Gallicano Hospital, UOC Of Hematology, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Majolino","sequence":"additional","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo\u2010Forlanini Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriella","family":"Mazzucconi","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza\u201d Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Vianelli","sequence":"additional","affiliation":[{"name":"Institute of Hematology \u201cL. And a. Ser\u00e0gnoli\u201d, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, S. Orsola\u2010Malpighi Hospital  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Alimena","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology University \u201cLa Sapienza\u201d Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Montanaro","sequence":"additional","affiliation":[{"name":"Hematology, Belcolle Hospital Viterbo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Palandri","sequence":"additional","affiliation":[{"name":"Institute of Hematology \u201cL. And a. Ser\u00e0gnoli\u201d, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, S. 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